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Influence of CT-based depth correction of renal scintigraphy in evaluation of living kidney donors on side selection and postoperative renal function: is it necessary to know the relative renal function?

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Abstract

Purpose

To analyse the influence of CT-based depth correction in the assessment of split renal function in potential living kidney donors.

Methods

In 116 consecutive living kidney donors preoperative split renal function was assessed using the CT-based depth correction. Influence on donor side selection and postoperative renal function of the living kidney donors were analyzed. Linear regression analysis was performed to identify predictors of postoperative renal function.

Results

A left versus right kidney depth variation of more than 1 cm was found in 40/114 donors (35%). 11 patients (10%) had a difference of more than 5% in relative renal function after depth correction. Kidney depth variation and changes in relative renal function after depth correction would have had influence on side selection in 30 of 114 living kidney donors. CT depth correction did not improve the predictability of postoperative renal function of the living kidney donor. In general, it was not possible to predict the postoperative renal function from preoperative total and relative renal function. In multivariate linear regression analysis, age and BMI were identified as most important predictors for postoperative renal function of the living kidney donors.

Conclusions

Our results clearly indicate that concerning the postoperative renal function of living kidney donors, the relative renal function of the donated kidney seems to be less important than other factors. A multimodal assessment with consideration of all available results including kidney size, location of the kidney and split renal function remains necessary.

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Authors and Affiliations

  1. Department of Urology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany

    Sarah Weinberger, Carola Klarholz-Pevere & Frank Friedersdorff

  2. Department of Nephrology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

    Lutz Liefeldt

  3. Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

    Michael Baeder

  4. Department of Internal and Complementary Medicine, Immanuel Hospital and Institute of Social Medicine, Epidemiology and Health Economics, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

    Nico Steckhan

Authors
  1. Sarah Weinberger
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  2. Carola Klarholz-Pevere
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  3. Lutz Liefeldt
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  4. Michael Baeder
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  5. Nico Steckhan
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  6. Frank Friedersdorff
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Contributions

SW manuscript writing, CK data collection and management. LL manuscript editing. MB protocol/project development. NS data analysis. FF manuscript writing and editing.

Corresponding author

Correspondence to Frank Friedersdorff.

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Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

No human participants or animals were involved into this study.

Informed consent

Because of the retrospective analysis no informed consent were needed.

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Weinberger, S., Klarholz-Pevere, C., Liefeldt, L. et al. Influence of CT-based depth correction of renal scintigraphy in evaluation of living kidney donors on side selection and postoperative renal function: is it necessary to know the relative renal function?. World J Urol 36, 1327–1332 (2018). https://doi.org/10.1007/s00345-018-2272-0

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  • DOI: https://doi.org/10.1007/s00345-018-2272-0

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