Skip to main content
SpringerLink
Log in

Osteoid osteoma and osteoid osteoma-mimicking lesions: biopsy findings, distinctive MDCT features and treatment by radiofrequency ablation

  • Musculoskeletal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objective:

To report the biopsy findings of osteoid osteoma (OO) and OO-mimicking lesions, assess their distinctive multidetector computed tomography (MDCT) features and evaluate treatment by radiofrequency ablation (RFA).

Methods:

In this multicentric retrospective study, 80 patients (54 male, 26 female, mean age 24.1 years, range 5–48) with presumed (clinical and MDCT features) OO were treated by percutaneous RFA between May 2002 and June 2009. Per-procedural biopsies were always performed. The following MDCT features were assessed: skeletal distribution and location within the bone, size, central calcification, surrounding osteosclerosis and periosteal reaction. Clinical success of RFA was evaluated.

Results:

Histopathological diagnoses were: 54 inconclusive biopsies, 16 OO, 10 OO-mimicking lesions (5 chronic osteomyelitis, 3 chondroblastoma, 1 eosinophilic granuloma, 1 fibrous dysplasia). OO-mimicking lesions were significantly greater in size (p = 0.001) and presented non-significant trends towards medullary location (p = 0.246), moderate surrounding osteosclerosis (p = 0.189) and less periosteal reaction (p = 0.197), compared with OO. Primary success for ablation of OO-mimicking lesions was 100% at 1 month, 85.7% at 6 and 12 months, and 66.7% at 24 months. Secondary success was 100%.

Conclusion:

Larger size, medullary location, less surrounding osteosclerosis and periosteal reaction on MDCT may help differentiate OO-mimicking lesions from OO. OO-mimicking lesions are safely and successfully treated by RFA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Unni KK (1996) Dahlin’s bone tumours: general aspects and data on 11,087 cases, 5th edn. Lippincott-Raven, Philadelphia, pp 121–142

    Google Scholar 

  2. Assoun J, Richardi G, Railhac JJ et al (1994) Osteoid osteoma: MR imaging versus CT. Radiology 191:217–223

    CAS  PubMed  Google Scholar 

  3. Davies M, Cassar-Pullicino VN, Davies AM, McCall IW, Tyrrell PN (2002) The diagnostic accuracy of MR imaging in osteoid osteoma. Skeletal Radiol 31:559–569

    Article  PubMed  Google Scholar 

  4. Kransdorf MJ, Stull MA, Gilkey FW, Moser RP Jr (1991) Osteoid osteoma. Radiographics 11:671–696

    CAS  PubMed  Google Scholar 

  5. Sans N, Galy-Fourcade D, Assoun J et al (1999) Osteoid osteoma: CT-guided percutaneous resection and follow-up in 38 patients. Radiology 212:687–692

    CAS  PubMed  Google Scholar 

  6. Abril JC, Castillo F, Casas J, Díaz A (2000) Brodie's abscess of the hip simulating osteoid osteoma. Orthopedics 23:285–287

    CAS  PubMed  Google Scholar 

  7. Ishida T, Goto T, Motoi N, Mukai K (2002) Intracortical chondroblastoma mimicking intra-articular osteoid osteoma. Skeletal Radiol 31:603–607

    Article  PubMed  Google Scholar 

  8. Corby RR, Stacy GS, Peabody TD, Dixon LB (2008) Radiofrequency ablation of solitary eosinophilic granuloma of bone. AJR Am J Roentgenol 190:1492–1494

    Article  PubMed  Google Scholar 

  9. Ramnath RR, Rosenthal DI, Cates J, Gebhardt M, Quinn RH (2002) Intracortical chondroma simulating osteoid osteoma treated by radiofrequency. Skeletal Radiol 31:597–602

    Article  PubMed  Google Scholar 

  10. Takenaga RK, Frassica FJ, McCarthy EF (2007) Subperiosteal chondromyxoid fibroma: a report of two cases. Iowa Orthop J 27:104–107

    PubMed  Google Scholar 

  11. Schajowicz F, Rebecchini AC, Bosch-Mayol G (1979) Intracortical haemangioma simulating osteoid osteoma. J Bone Joint Surg Br 61:94–95

    CAS  PubMed  Google Scholar 

  12. Resnick D (1995) Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. In: Resnick D (ed) Diagnosis of bone and joint disorders, 3rd edn. Saunders, Philadelphia, pp 3786–3796

    Google Scholar 

  13. Reeder MM (2003) Reeder and Felson’s Gamuts in radiology: comprehensive lists of roentgen differential diagnosis, 4th edn. Springer, New York, Gamut D-64 p 299

    Google Scholar 

  14. Helms CA, Hattner RS, Vogler JB 3rd (1984) Osteoid osteoma: radionuclide diagnosis. Radiology 151:779–784

    CAS  PubMed  Google Scholar 

  15. von Kalle T, Langendörfer M, Fernandez FF, Winkler P (2009) Combined dynamic contrast-enhancement and serial 3D-subtraction analysis in magnetic resonance imaging of osteoid osteomas. Eur Radiol 19:2508–2517

    Article  Google Scholar 

  16. Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ (2003) Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology 229:171–175

    Article  PubMed  Google Scholar 

  17. Gangi A, Alizadeh H, Wong L, Buy X, Dietemann JL, Roy C (2007) Osteoid osteoma: percutaneous laser ablation and follow-up in 114 patients. Radiology 242:293–301

    Article  PubMed  Google Scholar 

  18. Sim FH, Dahlin CD, Beabout JW (1975) Osteoid-osteoma: diagnostic problems. J Bone Joint Surg Am 57:154–159

    CAS  PubMed  Google Scholar 

  19. Lee GK, Kang IW, Lee ES, Min SJ, Cho SW, Hwang DH (2004) Osteoid osteoma of the tarsal cuboid mimicking osteomyelitis. AJR Am J Roentgenol 183:341–342

    PubMed  Google Scholar 

  20. Levine E, Neff JR (1983) Dynamic computed tomography scanning of benign bone lesions: preliminary results. Skeletal Radiol 9:238–245

    Article  CAS  PubMed  Google Scholar 

  21. Laredo JD, Hamze B, Jeribi R (2009) Percutaneous biopsy of osteoid osteomas prior to percutaneous treatment using two different biopsy needles. Cardiovasc Intervent Radiol 32:998–1003

    Article  PubMed  Google Scholar 

  22. Hoffmann RT, Jakobs TF, Kubisch CH et al (2009) Radiofrequency ablation in the treatment of osteoid osteoma-5-year experience. Eur J Radiol 73:374–379

    Article  PubMed  Google Scholar 

  23. Cantwell CP, Obyrne J, Eustace S (2004) Current trends in treatment of osteoid osteoma with an emphasis on radiofrequency ablation. Eur Radiol 14:607–617

    Article  PubMed  Google Scholar 

  24. Rybak LD, Rosenthal DI, Wittig JC (2009) Chondroblastoma: radiofrequency ablation–alternative to surgical resection in selected cases. Radiology 251:599–604

    Article  PubMed  Google Scholar 

  25. Tins B, Cassar-Pullicino V, McCall I, Cool P, Williams D, Mangham D (2006) Radiofrequency ablation of chondroblastoma using a multi-tined expandable electrode system: initial results. Eur Radiol 16:804–810

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We gratefully thank Dr. Mohamed Faouzi for assistance with his statistical analysis and Dr. Alexandre Sobotka for help in figures editing.

Author information

Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011, Lausanne, Switzerland

    Fabio Becce & Nicolas Theumann

  2. Department of Radiology B, Hôpital Cochin, AP-HP, Université Paris Descartes, Rue du Faubourg Saint-Jacques 27, 75014, Paris, France

    Fabio Becce, Antoine Rochette, Raphaël Campagna, Jean-Luc Drapé & Antoine Feydy

  3. Department of Anatomic Pathology, Hôpital Cochin, AP-HP, Université Paris Descartes, 75014, Paris, France

    Frédérique Larousserie

  4. Department of Orthopaedic and Traumatologic Surgery, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland

    Stéphane Cherix & Elyazid Mouhsine

  5. University Institute of Pathology, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland

    Louis Guillou

  6. Department of Orthopaedic Surgery, Hôpital Cochin, AP-HP, Université Paris Descartes, 75014, Paris, France

    Philippe Anract

Authors
  1. Fabio Becce
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicolas Theumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antoine Rochette
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Frédérique Larousserie
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Raphaël Campagna
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Stéphane Cherix
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Louis Guillou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Elyazid Mouhsine
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Philippe Anract
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jean-Luc Drapé
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Antoine Feydy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Antoine Feydy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Becce, F., Theumann, N., Rochette, A. et al. Osteoid osteoma and osteoid osteoma-mimicking lesions: biopsy findings, distinctive MDCT features and treatment by radiofrequency ablation. Eur Radiol 20, 2439–2446 (2010). https://doi.org/10.1007/s00330-010-1811-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-010-1811-x

Keywords

Search

Navigation