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Association between disease activity measured by RAPID3 and health-related quality of life in patients with rheumatoid arthritis

  • Observational Research
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Abstract

Routine assessment of patient index data 3 (RAPID3) is a simple, valid and reliable tool designed to measure disease activity in patients with rheumatoid arthritis (RA). RA causes significant disability and diminishes health-related quality of life (HR-QoL). The aim of this study was to investigate how RAPID3 is related to HR-QoL in patients with RA. In this cross-sectional study performed at the tertiary outpatient clinic 68 consecutive patients (58 females, and 10 males) with established RA were enrolled. RAPID3 and EuroQoL-5D-3L (EQ-5D-3L) were used to measure disease activity and quality of life, respectively. Alongside, demographic and clinical data were obtained, as well as HAQ-DI as a measure of physical function, and Steinbrocker’s score for radiographic damage. To test the relationships among RAPID3 and study variables we used the Pearson product–moment correlation coefficient, with the significance was set at P < 0.05. Linear and forward stepwise regression was used to show how variables of interest contributed to RAPID3. The mean value of RAPID3 (standard deviation, SD) was 14.12 (± 5.21), while the median (IQR) value of EQ-5D-3L was 0.51 (0.62–0.23). There was a high significant correlation (r = − 0.73) between RAPID3 scores and EQ-5D-3L. Among the other variables of interest, the strongest correlation was found between RAPID3 and intensity of pain (r = 0.88), while the EQ-5D-3L and pain were moderately correlated (r = − 0.68). In evaluating the influence of variables of interest on RAPID3, a forward stepwise regression model was constructed to evaluate whether VAS pain, EQ-5D-3L and EQ-VAS predicted RAPID3. The given variables significantly explained approximately 81% of the variation in RAPID3. Based on the results of this study RAPID3, a simple and practical tool to assess disease activity, reflects well HR-QoL in patients with established RA.

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Acknowledgements

We thank our patients for taking part in this research.

Funding

No funding was received for this study.

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Authors and Affiliations

  1. Clinic of Physical Medicine and Rehabilitation, University Clinical Centre of Kosovo, Pristina, Kosovo

    Merita Qorolli

  2. Rheumatology Clinic, University Clinical Centre of Kosovo, Pristina, Kosovo

    Blerta Rexhepi & Sylejman Rexhepi

  3. Department of Radiology, Southern Älvsborg Hospital, Borås, Sweden

    Matej Mustapić

  4. University Department for Rheumatology, Physical and Rehabilitation Medicine, University Hospital Centre Sestre Milosrdnice, Vinogradska c. 29, 10000, Zagreb, Croatia

    Ines Doko & Simeon Grazio

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  1. Merita Qorolli
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  4. Matej Mustapić
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  5. Ines Doko
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  6. Simeon Grazio
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Contributions

MQ, SR and BR were local investigators who contributed substantially to the acquisition of the data. MQ wrote the first version of the manuscript and undertook the statistical analyses. MQ, SR, BR undertook the data collection. MM and ID undertook the data interpretation and contributed to the writing and editing of the manuscript. SG developed the theoretical framework, supervised the study, and revised the manuscript. All authors participated in the interpretation of the results, editing, and approved the final version of the manuscript.

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Correspondence to Simeon Grazio.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Qorolli, M., Rexhepi, B., Rexhepi, S. et al. Association between disease activity measured by RAPID3 and health-related quality of life in patients with rheumatoid arthritis. Rheumatol Int 39, 827–834 (2019). https://doi.org/10.1007/s00296-019-04258-z

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