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Das Fettgewebe im Fokus des Immunsystems: adipositasassoziierte Inflammation

The immune system of adipose tissue: obesity-associated inflammation

  • Schwerpunkt: Unser Immunsystem - der Staat im Staate
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Zusammenfassung

Das Fettgewebe ist ein endokrines Organ. Mittels seiner Sekretionsprodukte kommuniziert es mit anderen Organsystemen und übermittelt den Füllstand der Energiereserven. Durch die übermäßige Ansammlung von Fettgewebe im Kontext der Adipositas kommt es zu einer Infiltration von Immunzellen. Dieser Übersichtsartikel stellt die verschiedenen Populationen von Immunzellen im Fettgewebe dar und diskutiert ihre lokalen und systemischen Einflüsse.

Abstract

Adipose tissue is an important endocrine organ. Via its secretion products, it cross-talks with other organs of the body and communicates the filling state of its triglyceride stores. Obesity is characterized by the excessive accumulation of body fat and leads to the infiltration and accumulation of immune cells in white adipose tissue. In this review article we introduce the various immune cell populations of adipose tissue and discuss their local and systemic influence.

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Danksagung

Wir danken Dr. Julia Zinngrebe, Dr. Julian Roos und Dr. Daniel Tews für die kritische Durchsicht des Manuskripts. Vielen Dank an Dr. Daniel Tews für die Bereitstellung der Übersichtsfärbungen von murinem Fettgewebe.

Förderung

Pamela Fischer-Posovszky wird im Heisenberg-Programm der Deutschen Forschungsgemeinschaft gefördert (Fi 1700/7-1).

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Authors and Affiliations

  1. Universitätsklinik für Kinder- und Jugendmedizin, Universitätsklinikum Ulm, Eythstr. 24, 89075, Ulm, Deutschland

    Pamela Fischer-Posovszky

  2. Institut für Pathologie, Universitätsklinikum Ulm, Ulm, Deutschland

    Peter Möller

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  1. Pamela Fischer-Posovszky
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Correspondence to Pamela Fischer-Posovszky.

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P. Fischer-Posovszky und P. Möller geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Peter Möller, Ulm

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Fischer-Posovszky, P., Möller, P. Das Fettgewebe im Fokus des Immunsystems: adipositasassoziierte Inflammation. Pathologe 41, 224–229 (2020). https://doi.org/10.1007/s00292-020-00782-z

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