Zusammenfassung
Ektopien des Mammagewebes können die gesamte Brust (akzessorische Mamma), den Drüsenkörper ohne Mamille (aberrierende Mamma) oder nur die Mamille betreffen (Polythelie). Sie entwickeln sich entlang der von der vorderen Axillarfalte bis in die Vulva reichenden, als Milchleiste bezeichneten embryonalen Anlage, sehr selten auch außerhalb davon. Die häufigsten Lokalisationen sind die Axilla, die reguläre Mamma und ihre unmittelbare Nachbarschaft. Von ektopen Mammagewebe ausgehende Tumoren wie Fibroadenome und Karzinome sind in Einzelfällen beschrieben.
Abstract
Ectopic breast tissue may represent the complete breast (accessory breast), glandular tissue without areola or nipple (aberrant breast tissue), or exclusively the nipple (polythelia). Localization is along the embryonic milk ridge extending from the axilla to the vulva. Only rarely, is ectopic tissue found outside of the milk ridge. Most frequently affected are the axilla, the breast itself, and its close neighbourhood. Ectopic breast tissue may rarely give rise to tumours such as fibroadenoma or carcinoma.
Literatur
Bässler R (1984) Pathologie der Brustdrüse. In: Remmele W (Hrsg) Pathologie, Bd. 3. Springer, Berlin, Heidelberg, New York, S 315
Carter JE, Mizell KN, Tucker JA (2008) Mammary-type fibroepithelial neoplasms of the vulva: a case report and review of the literature. J Cutan Pathol 35:246–249
Chung-Park M, Zheng Liu C, Giampoli EJ, Emery JD, Shalodi A (2002) Mucinous adenocarcinoma of ectopic breast tissue of the vulva. Arch Pathol Lab Med 126:1216–1218
Dzodic R, Stanojevic B, Saenko V, Nakashima M, Markovic I, Pupic G, Buta M, Inic M, Rogounovitch T, Yamashita S (2010) Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. Diagn Pathol 5:17
Edlow DW, Carter D (1973) Heterotopic epithelium in axillary lymph nodes: report of a case and review of the literature. Am J Clin Pathol 59:666–673
Fellegara G, Carcangiu ML, Rosai J (2011) Benign epithelial inclusions in axillary lymph nodes: report of 18 cases and review of the literature. Am J Surg Pathol 35:1123–1133
Francone E, Nathan MJ, Murelli F, Bruno MS, Traverso E, Friedman D (2013) Ectopic breast cancer: case report and review of the literature. Aesthetic Plast Surg 37:746–749
Intra M, Maggioni A, Sonzogni A, De Cicco C, Machado LS, Sagona A, Talakhadze N (2006) A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: case report and literature review. Int J Gynecol Cancer 16(Suppl 1):428–433
Kalyani R, Srinivas MV, Veda P (2014) Vulval fibroadenoma—a report of two cases with review of literature. Int J Biomed Sci 10:143–145
Kenney RD, Flippo JL, Black EB (1987) Supernumerary nipples and renal anomalies in neonates. Am J Dis Child 141(9):987–988. https://doi.org/10.1001/archpedi.1987.04460090064026
Lee J, Jung JH, Kim WW, Hwang SO, Kang JG, Baek J, Kim HJ, Park JY, Jeong JY, Lim JY, Park HY (2014) Ductal carcinoma arising from ectopic breast tissue following microcalcification observed on screening mammography: a case report and review of the literature. J Breast Cancer 17:393–396
Lopes G, DeCesare T, Ghurani G, Vincek V, Jorda M, Glück S, Silva O (2006) Primary ectopic breast cancer presenting as a vulvar mass. Clin Breast Cancer 7:278–279
Mannan AA, Kahvic M, Aziz AH (2010) Phyllodes tumor of the vulva: Report of a rare case and review of the literature. Am J Dermatopathol 32:384–386
Nardello SM, Kulkarni N, Aggon A, Boraas M, Sigurdson ER, Bleicher RJ (2015) Invasive mucinous carcinoma arising in ectopic axillary breast tissue: a case report and literature review. Am J Case Rep 16:153–159
Nihon-Yanagi Y, Ueda T, Kameda N, Okazumi S (2011) A case of ectopic breast cancer with a literature review. Surg Oncol 20(1):35–42
Piura B, Gemer O, Rabinovich A, Yanai-Inbar I (2002) Primary breast carcinoma of the vulva: case report and review of literature. Eur J Gynaecol Oncol 23:21–24
Radner H, Berger A, Schmid KO (1987) Mamma supernumeraria dorsalis interscapularis (paravertebralis). Ein klinisch-pathologischer Fallbericht mit Literaturübersicht. Pathologe 8:310–315
Rosen PP (2009) Rosen’s breast pathology. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia
Silton RM (1979) More glandular inclusions. Am J Surg Pathol 3:285–286
Troupis T, Michalinos A, Skandalakis P (2012) Intramammary lymph nodes: a question seeking for an answer or an answer seeking for a question? Breast 21:615–620
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
H. H. Kreipe und M. Christgen geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Additional information
Schwerpunktherausgeber
W. Saeger, Hamburg
K.W. Schmid, Essen
Rights and permissions
About this article
Cite this article
Kreipe, H.H., Christgen, M. Ektopien des Mammagewebes. Pathologe 39, 398–401 (2018). https://doi.org/10.1007/s00292-018-0468-0
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00292-018-0468-0