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B cells in glomerulonephritis: focus on lupus nephritis

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Abstract

The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.

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Abbreviations

SLE:

systemic lupus erythematosus

IC:

immune complex

DC:

dendritic cell

GN:

glomerulonephritis

APC:

antigen presenting cell

ANCA:

anti-neutrophil cytoplasmic antibody

BCR:

B cell receptor

ADCC:

antibody-dependent cell-mediated cytotoxicity

TLR:

Toll-like receptor

IL:

interleukin

ANA:

anti-nuclear antibody

dsDNA:

double stranded DNA

BAFF:

B cell activity factor

HNA:

human neutrophil antigen

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  1. Division of Renal Medicine, Department of Medicine and Cambridge Institute for Medical Research, University of Cambridge, Lab 5.15, Box 139 Addenbrooke’s Hospital, Cambridge, CB2 2XY, UK

    Menna R. Clatworthy & Kenneth G. C. Smith

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Clatworthy, M.R., Smith, K.G.C. B cells in glomerulonephritis: focus on lupus nephritis. Semin Immunopathol 29, 337–353 (2007). https://doi.org/10.1007/s00281-007-0092-1

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