Skip to main content
Log in

Does the order of busulfan and cyclophosphamide affect allogeneic stem cell transplantation related liver toxicity?

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Seydoux C, Medinger M, Gerull S, Halter J, Heim D, Chalandon Y et al (2020) Busulfan-cyclophosphamide versus cyclophosphamide-busulfan as conditioning regimen before allogeneic hematopoietic cell transplantation: a prospective randomized trial. Ann Hematol. 209-216. doi:https://doi.org/10.1007/s00277-020-04312-y

  2. McCune JS, Batchelder A, Deeg HJ, Gooley T, Cole S, Phillips B et al (2007) Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortality. Biol Blood Marrow Transplant 13(7):853–862. https://doi.org/10.1016/j.bbmt.2007.03.012

    Article  CAS  PubMed  Google Scholar 

  3. Cantoni N, Gerull S, Heim D, Halter J, Bucher C, Buser A, Tsakiris DA, Passweg J, Tichelli A, Stern M, Gratwohl A (2011) Order of application and liver toxicity in patients given BU and CY containing conditioning regimens for allogeneic hematopoietic SCT. Bone Marrow Transplant 46(3):344–349. https://doi.org/10.1038/bmt.2010.137

    Article  CAS  PubMed  Google Scholar 

  4. Hassan Z, Hellström-Lindberg E, Alsadi S, Edgren M, Hägglund H, Hassan M (2002) The effect of modulation of glutathione cellular content on busulphan-induced cytotoxicity on hematopoietic cells in vitro and in vivo. Bone Marrow Transplant 30(3):141–147. https://doi.org/10.1038/sj.bmt.1703615

    Article  CAS  PubMed  Google Scholar 

  5. Rajvanshi P, Shulman HM, Sievers EL, McDonald GB (2002) Hepatic sinusoidal obstruction after gemtuzumab ozogamicin (Mylotarg) therapy. Blood. 99(7):2310–2314. https://doi.org/10.1182/blood.V99.7.2310

    Article  CAS  PubMed  Google Scholar 

  6. Wadleigh M, Richardson PG, Zahrieh D, Lee SJ, Cutler C, Ho V, Alyea EP, Antin JH, Stone RM, Soiffer RJ, DeAngelo DJ (2003) Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation. Blood. 102(5):1578–1582. https://doi.org/10.1182/blood-2003-01-0255

    Article  CAS  PubMed  Google Scholar 

  7. National Comprehensive Cancer Network® NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Myeloid Leukemia. https://www.nccn.org/professionals/physician_gls/pdf/aml.pdf. Accessed 10 Jan 2021

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Keisuke Kidoguchi.

Ethics declarations

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kidoguchi, K., Kuniyoshi, Y. & Kataoka, Y. Does the order of busulfan and cyclophosphamide affect allogeneic stem cell transplantation related liver toxicity?. Ann Hematol 100, 1911–1912 (2021). https://doi.org/10.1007/s00277-021-04515-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-021-04515-x

Navigation