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Double somatic mosaic mutations in TET2 and DNMT3A—origin of peripheral T cell lymphoma in a case

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References

  1. Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S (2014) Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet 46(2):171–175. doi:10.1038/ng.2872

    Article  CAS  PubMed  Google Scholar 

  2. Palomero T, Couronne L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral. T Cell Lymphom 46(2):166–170. doi:10.1038/ng.2873

    CAS  Google Scholar 

  3. Lin TL, Nagata Y, Kao HW, Sanada M, Okuno Y, Huang CF, Liang DC, Kuo MC, Lai CL, Lee EH, Shih YS, Tanaka H, Shiraishi Y, Chiba K, Lin TH, Wu JH, Miyano S, Ogawa S, Shih LY (2014) Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations. Haematologica 99(1):28–36. doi:10.3324/haematol.2013.091249

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Aslanyan MG, Kroeze LI, Langemeijer SM, Koorenhof-Scheele TN, Massop M, van Hoogen P, Stevens-Linders E, van de Locht LT, Tonnissen E, van der Heijden A, da Silva-Coelho P, Cilloni D, Saglio G, Marie JP, Tang R, Labar B, Amadori S, Muus P, Willemze R, Marijt EW, de Witte T, van der Reijden BA, Suciu S, Jansen JH (2014) Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial. Ann Hematol 93(8):1401–1412. doi:10.1007/s00277-014-2055-7

    CAS  PubMed  Google Scholar 

  5. Couronne L, Bastard C, Bernard OA (2012) TET2 and DNMT3A mutations in human T-cell lymphoma. N Engl J Med 366(1):95–96. doi:10.1056/NEJMc1111708

    Article  CAS  PubMed  Google Scholar 

  6. Youssoufian H, Pyeritz RE (2002) Mechanisms and consequences of somatic mosaicism in humans. Nat Rev Genet 3(10):748–758. doi:10.1038/nrg906

    Article  CAS  PubMed  Google Scholar 

  7. Foulkes WD, Real FX (2013) Many mosaic mutations. Curr Oncol (Toronto, Ont) 20(2):85–87. doi:10.3747/co.20.1449

    CAS  Google Scholar 

  8. Frank SA (2014) Somatic mosaicism and disease. Curr Biol CB 24(12):R577–R581. doi:10.1016/j.cub.2014.05.021

    Article  CAS  Google Scholar 

  9. Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S (2012) Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia. Blood 120(7):1485–1488. doi:10.1182/blood-2012-02-406090

    Article  CAS  PubMed  Google Scholar 

  10. Ismael O, Shimada A, Hama A, Elshazley M, Muramatsu H, Goto A, Sakaguchi H, Tanaka M, Takahashi Y, Yinyan X, Fukuda M, Miyajima Y, Yamashita Y, Horibe K, Hanada R, Ito M, Kojima S (2012) De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics. Br J Haematol 158(1):129–137. doi:10.1111/j.1365-2141.2012.09140.x

    Article  CAS  PubMed  Google Scholar 

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Samples were obtained with written informed consent after approval by the ethics committee in the University of Tsukuba Hospital.

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The authors declare that they have no conflict of interest.

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Correspondence to Shigeru Chiba.

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Nguyen, T.B., Sakata-Yanagimoto, M., Nakamoto-Matsubara, R. et al. Double somatic mosaic mutations in TET2 and DNMT3A—origin of peripheral T cell lymphoma in a case. Ann Hematol 94, 1221–1223 (2015). https://doi.org/10.1007/s00277-015-2332-0

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  • DOI: https://doi.org/10.1007/s00277-015-2332-0

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