Skip to main content
Log in

MDR1 modulates apoptosis in CD34+ leukemic cells

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Shman TV, Fedasenka UU, Savitski VP, Aleinikova OV (2008) CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of Bcl-2 and MDR1 genes than CD34− cells in childhood AML. Ann Hematol 87(5):353–360

    Article  PubMed  CAS  Google Scholar 

  2. Sharom FJ (2008) ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics 9(1):105–127

    Article  PubMed  CAS  Google Scholar 

  3. Johnstone RW, Ruefli AA, Smyth MJ (2000) Multiple physiological functions for multidrug transporter P-glycoprotein. Trends Biochem Sci 25(1):1–6 Review

    Article  PubMed  CAS  Google Scholar 

  4. Robinson LJ, Roberts WK, Ling TT, Lamming D, Sternberg SS, Roepe PD (1997) Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry 36(37):11169–11178

    Article  PubMed  CAS  Google Scholar 

  5. Weisburg JH, Roepe PD, Dzekunov S, Scheinberg DA (1999) Intracellular pH and multidrug resistance regulate complement-mediated cytotoxicity of nucleated human cells. J Biol Chem 274(16):10877–10888

    Article  PubMed  CAS  Google Scholar 

  6. Sakaeda T, Nakamura T, Okumura K (2002) MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol Pharm Bull 25(11):1391–1400 Review

    Article  PubMed  CAS  Google Scholar 

  7. Chinn LW, Kroetz DL (2007) ABCB1 pharmacogenetics: progress, pitfalls, and promise. Clin Pharmacol Ther 81(2):265–269 Review

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gabriele Buda.

Additional information

Gabriele Buda, Enrico Orciuolo and Valentina Maggini contributed equally to this letter.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Buda, G., Orciuolo, E., Maggini, V. et al. MDR1 modulates apoptosis in CD34+ leukemic cells. Ann Hematol 87, 1017–1018 (2008). https://doi.org/10.1007/s00277-008-0515-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-008-0515-7

Keywords

Navigation