Skip to main content
SpringerLink
Log in

90Y-Radioembolization After Failed Portal Vein Embolization for Colorectal Liver Metastases: A Case Report

  • Case Report
  • Interventional Oncology
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

The main limiting factor for liver resection is insufficient future liver remnant (FLR). Portal vein embolization (PVE) is a standard of care treatment to induce FLR hypertrophy, but it is not always efficient. Radioembolization (RE) has a potential to induce liver hypertrophy for PVE-refractory patients. However, this was reported only for the patients with hepatocellular carcinoma. We described two cases of lobar RE after PVE failure for the patients with colorectal liver metastases. This enabled to reach sufficient FLR, provide good local disease control and bridge the patients to extended hepatectomy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Abulkhir A, et al. Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann Surg. 2008;247:49–57. https://doi.org/10.1097/SLA.0b013e31815f6e5b.

    Article  PubMed  Google Scholar 

  2. Pamecha V, et al. Long-term survival and disease recurrence following portal vein embolisation prior to major hepatectomy for colorectal metastases. Ann Surg Oncol. 2009;16:1202–7. https://doi.org/10.1245/s10434-008-0269-4.

    Article  PubMed  Google Scholar 

  3. Fernandez-Ros N, et al. Partial liver volume radioembolization induces hypertrophy in the spared hemiliver and no major signs of portal hypertension. HPB Offic J Int Hepato Pancreato Biliary Assoc. 2014;16:243–9. https://doi.org/10.1111/hpb.12095.

    Article  Google Scholar 

  4. Vouche M, et al. Radiation lobectomy: time-dependent analysis of future liver remnant volume in unresectable liver cancer as a bridge to resection. J Hepatol. 2013;59:1029–36. https://doi.org/10.1016/j.jhep.2013.06.015.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Theysohn JM, et al. Hepatic volume changes after lobar selective internal radiation therapy (SIRT) of hepatocellular carcinoma. Clin Radiol. 2014;69:172–8. https://doi.org/10.1016/j.crad.2013.09.009.

    Article  CAS  PubMed  Google Scholar 

  6. Teo JY, et al. A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90. HPB Offic J Int Hepato Pancreato Biliary Assoc. 2016;18:7–12. https://doi.org/10.1016/j.hpb.2015.07.002.

    Article  Google Scholar 

  7. Bouazza F, et al. Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma. World J Gastroenterol. 2015;21:9666–700. https://doi.org/10.3748/wjg.v21.i32.9666.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Madoff DC, et al. Transhepatic portal vein embolization: anatomy, indications, and technical considerations. Radiogr Rev Publ Radiol Soc N Am. 2002;22:1063–76. https://doi.org/10.1148/radiographics.22.5.g02se161063.

    Article  Google Scholar 

  9. May BJ, Madoff DC. Portal vein embolization: rationale, technique, and current application. Semin Interv Radiol. 2012;29:81–9. https://doi.org/10.1055/s-0032-1312568.

    Article  Google Scholar 

  10. Kang BK, et al. Transcatheter arterial chemoembolization for hepatocellular carcinoma after attempted portal vein embolization in 25 patients. AJR Am J Roentgenol. 2009;193:W446–451. https://doi.org/10.2214/ajr.09.2479.

    Article  PubMed  Google Scholar 

  11. Wallace MJ, Ahrar K, Madoff DC. Chemoembolization of the liver after portal vein embolization: report of three cases. J Vasc Interv Radiol JVIR. 2008;19:1513–7. https://doi.org/10.1016/j.jvir.2008.07.010.

    Article  PubMed  Google Scholar 

  12. Radunz S, et al. Hepatic artery and biliary complications in liver transplant recipients with radioembolization bridging treatment for hepatocellular carcinoma. Clin Transplant. 2017. https://doi.org/10.1111/ctr.13096.

    Article  PubMed  Google Scholar 

  13. Pardo F, et al. The post-SIR-spheres surgery study (P4S): retrospective analysis of safety following hepatic resection or transplantation in patients previously treated with selective internal radiation therapy with Yttrium-90 resin microspheres. Ann Surg Oncol. 2017;24:2465–73. https://doi.org/10.1245/s10434-017-5950-z.

    Article  PubMed  Google Scholar 

  14. Martin AN, et al. Clinical factors and postoperative impact of bile leak after liver resection. J Gastrointest Surg Offic J Soc Surg Alimentary Tract. 2018;22:661–7. https://doi.org/10.1007/s11605-017-3650-4.

    Article  Google Scholar 

  15. Henry LR, et al. Liver resection for metastatic disease after y90 radioembolization: a case series with long-term follow-up. Ann Surg Oncol. 2015;22:467–74. https://doi.org/10.1245/s10434-014-4012-z.

    Article  PubMed  Google Scholar 

  16. Livraghi T, et al. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology. 2003;226:441–51. https://doi.org/10.1148/radiol.2262012198.

    Article  PubMed  Google Scholar 

  17. Livraghi T, et al. Percutaneous radiofrequency ablation of liver metastases in potential candidates for resection: the "test-of-time approach". Cancer. 2003;97:3027–35. https://doi.org/10.1002/cncr.11426.

    Article  PubMed  Google Scholar 

  18. Lambert LA, Colacchio TA, Barth RJ Jr. Interval hepatic resection of colorectal metastases improves patient selection. Arch Surg. 2000;135:473–9. https://doi.org/10.1001/archsurg.135.4.473.

    Article  CAS  PubMed  Google Scholar 

  19. Kito Y, Nagino M, Nimura Y. Doppler sonography of hepatic arterial blood flow velocity after percutaneous transhepatic portal vein embolization. Am J Roentgenol. 2001;176:909–12. https://doi.org/10.2214/ajr.176.4.1760909.

    Article  CAS  Google Scholar 

  20. Kennedy A, et al. Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: expert consensus. J Gastrointest Oncol. 2017;8:1079–99. https://doi.org/10.21037/jgo.2017.09.10.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, NL, The Netherlands

    I. Kurilova & F. M. Gomez

  2. GROW School for Oncology and Developmental Biology, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, NL, The Netherlands

    I. Kurilova

  3. Department of Radiology, Hospital Clinic de Barcelona, Carrer de Villarroel, 170, 08036, Barcelona, ES, Spain

    V. Pompa & F. M. Gomez

  4. Department of Radiology, Hospital de La Santa Creu I Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, ES, Spain

    R. Guerrero

  5. Department of Nuclear Medicine, Hospital Clinic de Barcelona, Carrer de Villarroel, 170, 08036, Barcelona, ES, Spain

    Mesa A. Tapias

  6. Department of Surgery, Hospital Universitari I Politecnic La Fe, Valencia, Avinguda de Fernando Abril Martorell, 106, 46026, Valencia, ES, Spain

    Mizrrahi D. Calatayud

  7. Department of Surgery, Hospital Clinic de Barcelona, Carrer de Villarroel, 170, 08036, BarcelonaBarcelona, ES, Spain

    C. Fondevila

  8. Department of Surgery, Hospital de La Santa Creu I Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, ES, Spain

    J. A. González

  9. Department of Nuclear Medicine, Hospital de La Santa Creu I Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, ES, Spain

    J. Duch

Authors
  1. I. Kurilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Pompa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Guerrero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mesa A. Tapias
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mizrrahi D. Calatayud
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Fondevila
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. A. González
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. Duch
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. F. M. Gomez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to F. M. Gomez.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical Approval and Informed Consent Statements

IRB approval was not required for this type of study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kurilova, I., Pompa, V., Guerrero, R. et al. 90Y-Radioembolization After Failed Portal Vein Embolization for Colorectal Liver Metastases: A Case Report. Cardiovasc Intervent Radiol 43, 1232–1236 (2020). https://doi.org/10.1007/s00270-020-02537-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-020-02537-y

Keywords

Search

Navigation