Abstract
Introduction
Accurate localization of the pathological parathyroid gland is a prerequisite for minimally invasive surgical management of hyperparathyroidism (HPT). Poor imaging or discordance in odd situations like ectopic adenomas, parathyroid hyperplasia, syndromic HPT results in localization dilemma thus causing failed parathyroidectomy. We studied the impact of Fluoro-Choline (FCH) PET/CT imaging in reduction in localization failure of parathyroid adenoma.
Materials and methods
We did a retrospective observational study (2018–2021) of HPT among which 97 patients underwent focused parathyroidectomy (FP). All patients had undergone ultrasound imaging and 99mTc-sestaMIBI scan with early SPECT/CT (MIBI). When this preliminary imaging was doubtful or negative or multiple lesions were expected, FCH PET/CT was performed. We compared the localization accuracy of MIBI scan and FCH PET/CT with surgical outcomes as reference standard.
Results
MIBI scan showed overall lesion detection rate (LDR) of 88.65% in localization of pathological parathyroid gland in 97 patients. The addition of FCH PET/CT improved the overall lesion detection to 97.9%. The overall possible localization failure was reduced from 11.34 to 2.06% with the addition of FCH PET/CT (p < 0.05).
Out of 97 patients of FP, 87 patients showed features of parathyroid adenoma. Single hyperplastic gland was seen in 7 patients, lipoadenoma was seen in 1 patient and 1 patient had features suggestive of parathyroiditis on histopathology. FCH PET/CT was a useful adjunct and showed significant reduction in localization failure of parathyroid adenoma.
Similar content being viewed by others
References
Zajíčková K, Zogala D, Kubinyi J (2018) Parathyroid imaging by 18F-fluorocholine PET/CT in patients with primary hyperparathyroidism and inconclusive conventional methods clinico-pathological correlations. Physiol Res. https://doi.org/10.33549/physiolres.934029
Quak E, Blanchard D, Houdu B, Le Roux Y, Ciappuccini R, Lireux B et al (2018) F18-choline PET/CT guided surgery in primary hyperparathyroidism when ultrasound and MIBI SPECT/CT are negative or inconclusive: the APACH1 study. Eur J Nucl Med Mol Imaging 45(4):658–666
Chen YH, Chen HT, Lee MC, Liu SH, Wang LY, Lue KH et al (2020) Preoperative F-18 fluorocholine PET/CT for the detection of hyperfunctioning parathyroid glands in patients with secondary or tertiary hyperparathyroidism: comparison with Tc-99m sestamibi scan and neck ultrasound. Ann Nucl Med 34(8):527–537
Huber GF, Hüllner M, Schmid C, Brunner A, Sah B, Vetter D et al (2018) Benefit of 18F-fluorocholine PET imaging in parathyroid surgery. Eur Radiol 28(6):2700–2707
Hope TA, Graves CE, Calais J, Ehman EC, Johnson GB, Thompson D et al (2021) Accuracy of 18F-fluorocholine PET for the detection of parathyroid adenomas: prospective single-center study. J Nucl Med 62(11):1511–1516
Prabhu M, Damle N (2018) Fluorocholine PET imaging of parathyroid disease. Indian J Endocr Metab 22(4):535
Broos WAM, Wondergem M, van der Zant FM, Schaper NC, Knol RJJ (2020) Dynamic 18F-fluorocholine PET/CT for parathyroid imaging in patients with primary hyperparathyroidism. Nucl Med Commun 41(8):776–782
Grimaldi S, Young J, Kamenicky P, Hartl D, Terroir M, Leboulleux S et al (2018) Challenging pre-surgical localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism: the added value of 18F-Fluorocholine PET/CT. Eur J Nucl Med Mol Imaging 45(10):1772–1780
Kim SJ, Lee SW, Jeong SY, Pak K, Kim K (2018) Diagnostic performance of F-18 fluorocholine PET/CT for parathyroid localization in hyperparathyroidism: a systematic review and meta-analysis. HORM CANC 9(6):440–447
Arora S, Damle NA, Passah A, Yadav MP, Ballal S, Aggarwal V et al (2018) Incidental detection of parathyroid adenoma on somatostatin receptor PET/CT and incremental role of 18F-fluorocholine PET/CT in MEN1 syndrome. Nucl Med Mol Imaging 52(3):238–242
Whitman J, Allen IE, Bergsland EK, Suh I, Hope TA (2021) Assessment and comparison of 18F-fluorocholine PET and 99 m Tc-sestamibi scans in identifying parathyroid adenomas: a metaanalysis. J Nucl Med 62(9):1285–1291
Amadou C, Bera G, Ezziane M, Chami L, Delbot T, Rouxel A et al (2019) 18F-fluorocholine PET/CT and parathyroid 4D computed tomography for primary hyperparathyroidism: the challenge of reoperative patients. World J Surg 43(5):1232–1242. https://doi.org/10.1007/s00268-019-04910-6
Lezaic L, Rep S, Sever MJ, Kocjan T, Hocevar M, Fettich J (2014) 18F-fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study. Eur J Nucl Med Mol Imaging 41(11):2083–2089
Hope TA, Graves CE, Calais J, Ehman EC, Johnson GB, Thompson D, Aslam M, Duh QY, Gosnell JE, Shen WT, Roman SA, Sosa JA, Kluijfhout WP, Seib CD, Villaneuva-Meyer JE, Pampaloni MH, Suh I (2021) Accuracy of 18F-fluorocholine PET for the detection of parathyroid adenomas: prospective single-center study. J Nucl Med 62(11):1511–1516
Kluijfhout WP, Vorselaars WM, van den Berk SA, Vriens MR, Borel Rinkes IH, Valk GD, van Dalen T, de Klerk JM, de Keizer B (2016) Fluorine-18 fluorocholine PET-CT localizes hyperparathyroidism in patients with inconclusive conventional imaging: a multicenter study from the Netherlands. Nucl Med Commun 37(12):1246–1252
Kluijfhout WP, Vorselaars WM, Vriens MR, Borel Rinkes IH, Valk GD, de Keizer B (2015) Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of (18)F-fluorocholine PET-CT. Eur J Radiol 84(9):1745–1751
Michaud L, Burgess A, Huchet V, Lefèvre M, Tassart M, Ohnona J et al (2014) Is 18F-fluorocholine-positron emission tomography/computerized tomography a new imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism? J Clin Endocrinol Metab 99(12):4531–4536
Latge A, Riehm S, Vix M, Bani J, Ignat M, Pretet V et al (2021) 18F-Fluorocholine PET and 4D-CT in patients with persistent and recurrent primary hyperparathyroidism. Diagnostics 11(12):2384
Acknowledgments
I express my sincere gratitude to Dr. Vuthaluru Seenu, Dr. Danny Joy, Dr. Anurag Srivastava, and Rajendra Aphale for their kind contribution in this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There is no conflict of interest in this study.
Informed consent
Informed consent was obtained from all the participants in this study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Aphale, R., Damle, N., Chumber, S. et al. Impact of Fluoro-Choline PET/CT in Reduction in Failed Parathyroid Localization in Primary Hyperparathyroidism. World J Surg 47, 1231–1237 (2023). https://doi.org/10.1007/s00268-022-06866-6
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-022-06866-6