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Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity

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Abstract

Fc receptors (FcRs) and the microbiome are both known to have an effect on the development and progression of cancers. Checkpoint inhibitors are a novel class of therapeutics which are used to combat cancer and are integrally linked to both FcRs and the microbiome. The use of checkpoint inhibitors has grown exponentially over the past decade, although many host factors affect both the efficacy and the safety of these therapeutics. Some of these host factors, including the microbiome and the expression of FcRs, are currently being investigated. Here we discuss the current understanding of FcRs (particularly the inhibitory FcγRIIB) and the microbiome in context of T cell immunity, inflammation, cancer, and checkpoint inhibition.

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Funding

KMB and MLF are both supported by grant R01 AI073707 to Mandy L. Ford.

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  1. Division of Transplant, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA

    Kirsten M. Baecher & Mandy L. Ford

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All authors contributed to the study conception and design. Literature review was performed by KMB. The first draft of the manuscript was written by KMB, and MLF commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Mandy L. Ford.

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Baecher, K.M., Ford, M.L. Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity. Cancer Immunol Immunother 70, 3397–3404 (2021). https://doi.org/10.1007/s00262-021-03004-4

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