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Recommended administered activities for 68Ga-labelled peptides in paediatric nuclear medicine

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Abstract

Purpose

The aim of this study was to establish a method for determining administered activities for 68Ga-labelled peptides. Dose calculations were based on the weight-independent effective dose model proposed by the EANM paediatric dosage card for use in paediatric nuclear medicine.

Methods

Previously published time-integrated activity coefficients for 68Ga-DOTATATE, 68Ga-DOTATOC and 68Ga-pentixafor were used to calculate age-independent effective doses. Consequently, the corresponding weight-dependent effective dose coefficients were rescaled according to the formalism of the EANM dosage card to determine the radiopharmaceutical class of  68Ga-labelled peptides (“multiples”) and to calculate the baseline activities based on an upper limit for administered activity (185 MBq) in an adult.

Results

All calculated normalization factors suggest that the 68Ga-labelled peptides are class “B” radiopharmaceuticals. The baseline activity for all compounds is 12.8 MBq. In analogy to 18F-fluoride, we recommend a minimum activity of 14 MBq.

Conclusion

For paediatric nuclear medicine applications involving 68Ga-labelled peptides, we suggest determining administered activities based on the formalism proposed in this work. The corresponding effective doses from these procedures will remain age-independent.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany

    J. Soares Machado, S. Beykan, K. Herrmann & M. Lassmann

  2. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    K. Herrmann

Authors
  1. J. Soares Machado
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  2. S. Beykan
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  3. K. Herrmann
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  4. M. Lassmann
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Corresponding author

Correspondence to J. Soares Machado.

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Funding

Part of this work was financed by a scholarship from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), the development agency of the Brazilian Federal Government.

Conflict of interest

None.

Ethical approval

This article does not describe any studies with human participants or animals performed by any of the authors.

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Machado, J.S., Beykan, S., Herrmann, K. et al. Recommended administered activities for 68Ga-labelled peptides in paediatric nuclear medicine. Eur J Nucl Med Mol Imaging 43, 2036–2039 (2016). https://doi.org/10.1007/s00259-015-3289-x

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  • DOI: https://doi.org/10.1007/s00259-015-3289-x

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