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Current strategies and future prospects for enhancing microbial production of citric acid

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Abstract

Aspergillus niger and Yarrowia lipolytica are highly important in citric acid (CA) production. To further minimize the cost of CA bio-production using A. niger and Y. lipolytica, some strategies (e.g., metabolic engineering, efficient mutagenesis, and optimal fermentation strategies) were developed to enhance CA production and low-cost carbon sources were also utilized to decrease CA bio-production cost. In this review, we summarize the recent significant progresses in CA bio-production, including metabolic engineering, efficient mutagenesis and screening methods, optimal fermentation strategies, and use of low-cost carbon sources, and future prospects in this field are also discussed, which could help in the development of CA production industry.

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Funding

This work was supported financially by the National Natural Science Foundation of China (No. 11605259), the western talents program of the Chinese Academy of Sciences (Y706030XB0), and the Open Project Program of the Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, China (KLCCB-KF201802).

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  1. Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China

    Wei Hu, Wen-jian Li & Ji-hong Chen

  2. The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China

    Hai-quan Yang

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  1. Wei Hu
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Correspondence to Hai-quan Yang or Ji-hong Chen.

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Hu, W., Li, Wj., Yang, Hq. et al. Current strategies and future prospects for enhancing microbial production of citric acid. Appl Microbiol Biotechnol 103, 201–209 (2019). https://doi.org/10.1007/s00253-018-9491-6

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