Abstract
The insufficient basic and clinical knowledge about invasive mold infections necessitated to review aspergillosis rodent models. The scope of this review has two major aspects. (1) It briefly summarizes Aspergillus toxicoses, the adverse effects of Aspergillus mycotoxins, the virulence factors of Aspergillus fumigatus, and how mild Aspergillus infections can turn to immunosuppressive diseases, ultimately to lethal invasive pulmonary aspergillosis. (2) The second major aspect of the review deals with earlier and recent murine models of pulmonary aspergillosis. Particular attention will be paid to the development of unified and generally applicable methods to detect, follow, and combat aspergillosis by medical treatments. Additionally, the review raises the question of responsibility regarding the application of immunosuppressive agents that initiate, contribute, and aggravate aspergillosis. Future studies of immunosuppression by chemical agents impacting aspergillosis deserve more studies.
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Animal and human care
Animal experiments published earlier in Applied Microbiology and Biotechnology serving as base of this mini-review were carried out in our Experimental Animal Facility (reg. number III/3.-KÁT./2015) under the supervision of Animal Care Committee, University of Debrecen. The experimental protocol was approved by the Animal Care Committee (license number 2/2014 DEMAB). Animal experiments and care of research staff against A. fumigatus inhalation conformed to the European Community (86/609/EEC) and special guidelines of BSL2 (200/54/EC 16). Human protection included minimizing exposure to mold spores and respiratory protective facemask containing the standard FFP2 equivalent to N95 HEPA filter.
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Banfalvi, G. Improved and adopted murine models to combat pulmonary aspergillosis. Appl Microbiol Biotechnol 102, 6865–6875 (2018). https://doi.org/10.1007/s00253-018-9161-8
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DOI: https://doi.org/10.1007/s00253-018-9161-8