Abstract
Human leukocyte antigen (HLA) molecules play a key role in regulating the immune response towards infectious agents like human immunodeficiency virus type-1 (HIV-1). They have been shown to influence transmission as well as the progression of HIV-1 towards acquired immune deficiency syndrome (AIDS). Roles of HLA-A and HLA-B have been documented extensively; however, HLA-C has been poorly studied. In the present study, we have evaluated the role of HLA-C in discordant couple and mother-to-child cohorts. HLA-C*07 was higher both in HIV-1-infected spouses and infants as compared to exposed uninfected spouses and infants. However, this was not significant. HLA-C*15 was significantly higher in HIV-1-exposed uninfected babies as compared to infected babies. Lack of treatment in mothers and breastfeeding were significantly associated with HIV-1 transmission. HLA-C*07 may be a susceptible allele in HIV-1 transmission, whereas HLA-C*15 may be a protective allele in mother-to-child cohorts, independent of feeding options and treatment. These findings could be important in targeting immune responses via population-specific vaccine strategies against HIV-1.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M (2013) Influence of HLA-C expression level on HIV control. Science 340:87–91. https://doi.org/10.1126/science.1232685
Apps R, Del Prete GQ, Chatterjee P et al (2016) HIV-1 vpu mediates HLA-C downregulation. Cell Host Microbe 19:686–695. https://doi.org/10.1016/j.chom.2016.04.005
Bardeskar NS, Mania-Pramanik J (2016) HIV and host immunogenetics: unraveling the role of HLA-C. HLA 88:221–231. https://doi.org/10.1111/tan.12882
Chaudhari DV, Chavan VR, Ahir SP, Kerkar SC, Mehta PR, Mania-Pramanik J (2013) Human leukocyte antigen B distribution in HIV discordant cohort from India. Immunol Lett 156:1–6. https://doi.org/10.1016/j.imlet.2013.09.002
Cohen GB, Gandhi RT, Davis DM, Mandelboim O, Chen BK, Strominger JL, Baltimore D (1999) The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV- infected cells from NK cells. Immunity 10:661–671
Farquhar C, Rowland-Jones S, Mbori-Ngacha D, Redman M, Lohman B, Slyker J, Otieno P, Obimbo E, Rostron T, Ochieng J, Oyugi J, Bosire R, John-Stewart G (2004) Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission. AIDS Res Hum Retrovir 20:692–697. https://doi.org/10.1089/0889222041524616
Fellay J, Shianna KV, Ge D et al (2007) A whole-genome association study of major determinants for host control of HIV-1. Science 317:944–947. https://doi.org/10.1126/science.1143767
Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, de Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (2009) Common genetic variation and the control of HIV-1 in humans. PLoS Genet 5:e1000791. https://doi.org/10.1371/journal.pgen.1000791
Kaslow RA, Dorak T, Tang J(J) (2005) Influence of host genetic variation on susceptibility to HIV type 1 infection. J Infect Dis 191:S68–S77. https://doi.org/10.1086/425269
Mallal S, Nolan D, Witt C, Masel G, Martin AM, Moore C, Sayer D, Castley A, Mamotte C, Maxwell D, James I, Christiansen FT (2002) Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 359:727–732. https://doi.org/10.1016/S0140-6736(02)07873-X
Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215. https://doi.org/10.1093/nar/16.3.1215
Mofenson LM (2010) Antiretroviral drugs to prevent breastfeeding HIV transmission. Antivir Ther 15:537–553. https://doi.org/10.3851/IMP1574
National AIDS Control Organisation (2015) National Guidelines for HIV Testing. Available from: http://www.naco.gov.in/sites/default/files/National_Guidelines_for_HIV_Testing_21Apr2016.pdf
Peterson TA, Kimani J, Wachihi C, Bielawny T, Mendoza L, Thavaneswaran S, Narayansingh MJ, Kariri T, Liang B, Ball TB, Ngugi EN, Plummer FA, Luo M (2013) HLA class I associations with rates of HIV-1 seroconversion and disease progression in the Pumwani Sex Worker Cohort. Tissue Antigens 81:93–107. https://doi.org/10.1111/tan.12051
Shankarkumar U, Thakar M, Mehendale S et al (2003) Association of HLA B*3520, B*1801, and Cw*1507 with HIV-1 infection Maharashtra, India. J Acquir Immune Defic Syndr 34:113–114. https://doi.org/10.1097/00126334-200309010-00016
Shea PR, Shianna KV, Carrington M, Goldstein DB (2013) Host genetics of HIV acquisition and viral control. Annu Rev Med 64:203–217. https://doi.org/10.1146/annurev-med-052511-135400
Snary D, Barnstable CJ, Bodmer WF, Crumpton MJ (1977) Molecular structure of human histocompatibility antigens: the HLA-C series. Eur J Immunol 7:580–585. https://doi.org/10.1002/eji.1830070816
Tornatore M, Gonçalves CV, Mendoza-Sassi RA et al (2010) HIV-1 vertical transmission in Rio Grande, Southern Brazil. Int J STD AIDS 21:351–355. https://doi.org/10.1258/ijsa.2009.009033
Trachtenberg E, Erlich H (2001) A review of the role of human leukocyte antigen (HLA) system as a host immunogenetic factor influencing HIV transmission and progression to AIDS. In: Korber BT, Brander C, Haynes BF (eds) HIV Molecular Immunology 2001. Theoretical Biology and Biophysics group, LANL, Los Alamos, pp I43–60
Umapathy S, Pawar A, Ghosh K (2007) Specific human leukocyte antigen alleles associated with HIV-1 infection in an Indian population. J Acquir Immune Defic Syndr 44:489–490. https://doi.org/10.1097/QAI.0b013e31803133d8
Acknowledgements
We thank Ms. Shilpa Kerkar for her help in sample collection and the counselling staff at the collaborating hospital for their help in recruiting patients and their follow-up. NSB is supported by the University Grants Commission - Senior Research Fellowship (UGC-SRF).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Bardeskar, N.S., Chavan, V., Ahir-Bist, S. et al. Human leukocyte antigen (HLA)-C and its association with HIV-1 transmission in discordant couple and mother-to-child cohorts. Immunogenetics 70, 633–638 (2018). https://doi.org/10.1007/s00251-018-1075-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00251-018-1075-1