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E-cigarette or vaping product use-associated lung injury in the pediatric population: imaging features at presentation and short-term follow-up

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Abstract

Background

Cases of e-cigarette or vaping product use-associated lung injury (EVALI) have rapidly reached epidemic proportions, yet there remain limited reports within the literature on the associated imaging findings.

Objective

We describe the most common imaging findings observed on chest computed tomography (CT) and chest radiograph (CXR) at presentation and at short-term follow-up at our major pediatric hospital.

Materials and methods

A retrospective review of the electronic medical records was performed on all patients with suspected EVALI who were treated at a major pediatric hospital and 11 patients were included for analysis. Two board-certified pediatric radiologists then categorized the CXRs as either normal or abnormal, and further performed a systematic review of the chest CTs for imaging findings in the lungs, pleura and mediastinum. Interrater discordance was reconciled by consensus review.

Results

The 11 patients (9 males:2 females) ranged in age from 14 to 18 years. Gastrointestinal and constitutional symptoms were present in all patients, whereas shortness of breath and cough were reported in 5/11 and 6/11 patients, respectively. The CXR was abnormal in 10/11 patients, whereas all chest CTs were abnormal. The most common CT findings included consolidation, ground-glass opacities, interlobular septal thickening, lymphadenopathy and crazy-paving pattern. Almost all patients demonstrated subpleural sparing, and less than half also demonstrated peribronchovascular sparing. There was complete or near-complete resolution of imaging abnormalities in 5/6 patients with a median follow-up duration of 114 days.

Conclusion

Pulmonary opacities with subpleural and peribronchovascular sparing was a commonly observed pattern of EVALI in the pediatric population at this institution. A CXR may not be sufficiently sensitive in diagnosing EVALI, and radiologists and clinicians should exercise caution when excluding EVALI based on the lack of a pulmonary opacity. Caution should also be exercised when excluding EVALI solely based on the lack of respiratory symptoms. Despite extensive pulmonary involvement at presentation, findings may resolve on short-term follow-up imaging.

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Authors and Affiliations

  1. Department of Radiology, Baylor College of Medicine, One Baylor Plaza, BCM-310, Houston, TX, 77030, USA

    Kevin Yuqi Wang

  2. Edward B. Singleton Department of Radiology, Texas Children’s Hospital, Houston, TX, USA

    Siddharth P. Jadhav & R. Paul Guillerman

  3. Department of Pulmonary Medicine, Texas Children’s Hospital, Houston, TX, USA

    Naga Jaya Smitha Yenduri, Stanley A. Lee & Harold J. Farber

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  1. Kevin Yuqi Wang
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  2. Siddharth P. Jadhav
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  3. Naga Jaya Smitha Yenduri
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  4. Stanley A. Lee
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Correspondence to Kevin Yuqi Wang.

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Wang, K.Y., Jadhav, S.P., Yenduri, N.J.S. et al. E-cigarette or vaping product use-associated lung injury in the pediatric population: imaging features at presentation and short-term follow-up. Pediatr Radiol 50, 1231–1239 (2020). https://doi.org/10.1007/s00247-020-04698-x

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  • DOI: https://doi.org/10.1007/s00247-020-04698-x

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