Abstract
Salivary gland pathologies in children are frequent, particularly viral infections, but rarely need cross-sectional imaging. However, when a mass involves the salivary spaces (primarily or as a secondary invasion from other neck spaces) it may pose problems in the differential diagnosis and in immediate management. Infrequently, systemic autoimmune diseases can also involve the salivary parenchyma in children and correctly interpreting the constellation of findings in the whole body is critical for the diagnosis. Distinguishing between cystic and solid masses is the first step for radiologists in order to narrow down the diagnosis. Location and spatial extension are the most important elements differentiating cystic masses, while signal characteristics, internal structure and local invasion help in the differential diagnosis of solid masses.
Similar content being viewed by others
References
Weissman JL, Carrau RL (1998) Anterior facial vein and submandibular gland together: predicting the histology of submandibular masses with CT or MR imaging. Radiology 208:441–446
Boscolo-Rizzo P, Da Mosto MC (2009) Submandibular space infection: a potentially lethal infection. Int J Infect Dis 13:327–333
Otonari-Yamamoto M, Nakajima K, Tsuji Y et al (2010) Imaging of the mylohyoid muscle: separation of submandibular and sublingual spaces. AJR Am J Roentgenol 194:W431–W438
Ugga L, Ravanelli M, Pallottino AA et al (2017) Diagnostic work-up in obstructive and inflammatory salivary gland disorders. Acta Otorhinolaryngol Ital 37:83–93
Nanci A (2014) Ten Cate’s oral histology - E-Book: development, structure, and function, 8th edn. Elsevier Health Sciences, Amsterdam
Miletich I, Som P (2015) Embryology of the salivary glands: An update. AJNR Am J Neuroradiol 5:167
Lehotay M, Kunkel M, Wehrbein H (2004) Lacrimo-auriculo-dento-digital syndrome. Case report, review of the literature, and clinical spectrum. J Orofac Orthop 65:425–432
Ferreira AP, Gomez RS, Castro WH et al (2000) Congenital absence of lacrimal puncta and salivary glands: report of a Brazilian family and review. Am J Med Genet 94:32–34
Chadi MJ, Saint Georges G, Albert F et al (2017) Major salivary gland aplasia and hypoplasia in Down syndrome: review of the literature and report of a case. Clin Case Rep 5:939–944
Yilmaz YF, Titiz A, Yurur-Kutlay N et al (2010) Congenital bilateral parotid gland agenesis in Klinefelter syndrome. J Craniomaxillofac Surg 38:248–250
D’Arco F, Youssef A, Ioannidou E et al (2020) Temporal bone and intracranial abnormalities in syndromic causes of hearing loss: an updated guide. Eur J Radiol 123:108803
Østerhus IN, Skogedal N, Akre H et al (2012) Salivary gland pathology as a new finding in Treacher Collins syndrome. Am J Med Genet A 158A:1320–1325
Teymoortash A, Hoch S (2016) Congenital unilateral agenesis of the parotid gland: A case report and review of the literature. Case Rep Dent 2016:2672496
D’Ascanio L, Cavuto C, Martinelli M, Salvinelli F (2006) Radiological evaluation of major salivary glands agenesis. A case report. Minerva Stomatol 55:223–228
Miyamoto RT, Hamaker RC, Lingeman RE (1976) Goldenhar syndrome. Associated with submandibular gland hyperplasia and hemihypoplasia of the mobile tongue. Arch Otolaryngol 102:313–314
Kumar KA, Mahadesh J, Setty S (2013) Dysgenetic polycystic disease of the parotid gland: Report of a case and review of the literature. J Oral Maxillofac Pathol 17:248–252
Finn DG, Buchalter IH, Sarti E et al (1987) First branchial cleft cysts: clinical update. Laryngoscope 97:136–140
Aronsohn RS, Batsakis JG, Rice DH, Work WP (1976) Anomalies of the first branchial cleft. Arch Otolaryngol 102:737–740
D’Souza AR, Uppal HS, De R, Zeitoun H (2002) Updating concepts of first branchial cleft defects: a literature review. Int J Pediatr Otorhinolaryngol 62:103–109
Bagchi A, Hira P, Mittal K et al (2018) Branchial cleft cysts: a pictorial review. Pol J Radiol 83:e204–e209
Adams A, Mankad K, Offiah C, Childs L (2016) Branchial cleft anomalies: a pictorial review of embryological development and spectrum of imaging findings. Insights Imaging 7:69–76
La’porte SJ, Juttla JK, Lingam RK (2011) Imaging the floor of the mouth and the sublingual space. Radiographics 31:1215–1230
Edwards RM, Chapman T, Horn DL et al (2013) Imaging of pediatric floor of mouth lesions. Pediatr Radiol 43:523–535
Ellis GL (2007) Lymphoid lesions of salivary glands: Malignant and Benign. Medicina Oral, Patología Oral y Cirugía Bucal. http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462007000700003. Accessed 1 Apr 2020
Iro H, Zenk J (2014) Salivary gland diseases in children. GMS Curr Top Otorhinolaryngol Head Neck Surg 13:Doc06
Mehta D, Willging JP (2006) Pediatric salivary gland lesions. Semin Pediatr Surg 15:76–84
Inarejos Clemente EJ, Navallas M, Tolend M et al (2018) Imaging evaluation of pediatric parotid gland abnormalities. Radiographics 38:1552–1575
Jeffers L, Webster-Cyriaque JY (2011) Viruses and salivary gland disease (SGD): lessons from HIV SGD. Adv Dent Res 23:79–83
Yousem DM, Kraut MA, Chalian AA (2000) Major salivary gland imaging. Radiology 216:19–29
Chandak R, Degwekar S, Chandak M, Rawlani S (2012) Acute submandibular sialadenitis-a case report. Case Rep Dent 2012:615375
Abdel Razek AAK, Mukherji S (2017) Imaging of sialadenitis. Neuroradiol J 30:205–215
Madani G, Beale T (2006) Inflammatory conditions of the salivary glands. Semin Ultrasound CT MR 27:440–451
Francis CL, Larsen CG (2014) Pediatric sialadenitis. Otolaryngol Clin N Am 47:763–778
Wei Y, Xiao J, Pui MH, Gong Q (2008) Tuberculosis of the parotid gland: computed tomographic findings. Acta Radiol 49:458–461
Razek AA, Castillo M (2010) Imaging appearance of granulomatous lesions of head and neck. Eur J Radiol 76:52–60
Garg R, Verma SK, Mehra S, Srivastawa AN (2010) Parotid tuberculosis. Lung India 27:253–255
Muccio CF, Caranci F, D’Arco F et al (2014) Magnetic resonance features of pyogenic brain abscesses and differential diagnosis using morphological and functional imaging studies: a pictorial essay. J Neuroradiol 41:153–167
Hammenfors DS, Valim V, Bica BERG et al (2020) Juvenile Sjögren’s syndrome: clinical characteristics with focus on salivary gland ultrasonography. Arthritis Care Res (Hoboken) 72:78–87
Cimaz R, Casadei A, Rose C et al (2003) Primary Sjögren syndrome in the paediatric age: a multicentre survey. Eur J Pediatr 162:661–665
Ching AS, Ahuja AT (2002) High-resolution sonography of the submandibular space: anatomy and abnormalities. AJR Am J Roentgenol 179:703–708
Tonami H, Ogawa Y, Matoba M et al (1998) MR sialography in patients with Sjögren syndrome. AJNR Am J Neuroradiol 19:1199–1203
Izumi M, Eguchi K, Uetani M et al (1998) MR features of the lacrimal gland in Sjögren’s syndrome. AJR Am J Roentgenol 170:1661–1666
Means C, Aldape MA, King E (2017) Pediatric primary Sjögren syndrome presenting with bilateral ranulas: A case report and systematic review of the literature. Int J Pediatr Otorhinolaryngol 101:11–19
Karim F, Loeffen J, Bramer W et al (2016) IgG4-related disease: a systematic review of this unrecognized disease in pediatrics. Pediatr Rheumatol Online J 14:18
Geyer JT, Ferry JA, Harris NL et al (2010) Chronic sclerosing sialadenitis (Küttner tumor) is an IgG4-associated disease. Am J Surg Pathol 34:202–210
Melo JC, Kitsko D, Reyes-Múgica M (2012) Pediatric chronic sclerosing sialadenitis: Küttner tumor. Pediatr Dev Pathol 15:165–169
Fujita A, Sakai O, Chapman MN, Sugimoto H (2012) IgG4-related disease of the head and neck: CT and MR imaging manifestations. Radiographics 32:1945–1958
De Cocker LJ, D’Arco F, De Beule T et al (2014) IgG4-related systemic disease affecting the parotid and submandibular glands: magnetic resonance imaging features of IgG4-related chronic sclerosing sialadenitis and concomitant lymphadenitis. Clin Imaging 38:195–198
Wiegand S, Zimmermann AP, Eivazi B et al (2011) Lymphatic malformations involving the parotid gland. Eur J Pediatr Surg 21:242–245
Steiner JE, Drolet BA (2017) Classification of vascular anomalies: an update. Semin Interv Radiol 34:225–232
Som PM, Zimmerman RA, Biller HF (1984) Cystic hygroma and facial nerve paralysis: a rare association. J Comput Assist Tomogr 8:110–113
Lee GS, Perkins JA, Oliaei S, Manning SC (2008) Facial nerve anatomy, dissection and preservation in lymphatic malformation management. Int J Pediatr Otorhinolaryngol 72:759–766
Bhatt NK, Kang L-I, El-Mofty S et al (2018) Emergent parotidectomy after parotid lymphatic malformation hematoma. Otolaryngology Case Reports 7:16–18
Bansal AG, Oudsema R, Masseaux JA, Rosenberg HK (2018) US of pediatric superficial masses of the head and neck. Radiographics 38:1239–1263
Eren S, Bakir Z (2009) Imaging features of cervical lymphangiomas as a cause of respiratory distress and vascular-lymphatic disturbance. Eurasian J Med 41:39–43
Berry JA, Wolf JS, Gray WC (2002) Squamous cell carcinoma arising in a lymphangioma of the tongue. Otolaryngol Head Neck Surg 127:458–460
Linnaus ME, Notrica DM (2016) Infected cystic hygroma resulting in septic shock and respiratory failure: a case report. J Pediatr Surg Case Rep 9:19–22
Burusapat C, Sringkarawat S, Thanapurirat S et al (2018) An unusual presentation of idiopathic lymphatic cyst of the thigh. Case Rep Surg 2018:1–5
Tu JH, Do HM, Patel V et al (2017) Sclerotherapy for lymphatic malformations of the head and neck in the pediatric population. J Neurointerv Surg 9:1023–1026
Bentz BG, Hughes CA, Lüdemann JP, Maddalozzo J (2000) Masses of the salivary gland region in children. Arch Otolaryngol Head Neck Surg 126:1435–1439
Darrow DH, Greene AK, Mancini AJ et al (2015) Diagnosis and management of infantile hemangioma. Pediatrics 136:e1060–e1104
North PE, Waner M, Mizeracki A, Mihm MC Jr (2000) GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 31:11–22
Smith CJF, Friedlander SF, Guma M et al (2017) Infantile hemangiomas: an updated review on risk factors, pathogenesis, and treatment. Birth Defects Res 109:809–815
Vilanova JC, Barceló J, Smirniotopoulos JG et al (2004) Hemangioma from head to toe: MR imaging with pathologic correlation. Radiographics 24:367–385
Bhat V, Salins PC, Bhat V (2014) Imaging spectrum of hemangioma and vascular malformations of the head and neck in children and adolescents. J Clin Imaging Sci 4:31
Rai A, Kumar A (2015) Neurofibroma of facial nerve presenting as parotid mass. J Maxillofac Oral Surg 14:465–468
Ahmedi JR, Ahmedi E, Perjuci F et al (2017) Pleomorphic adenoma of minor salivary glands in child. Med Arch 71:360–363
Ikeda K, Katoh T, Ha-Kawa SK et al (1996) The usefulness of MR in establishing the diagnosis of parotid pleomorphic adenoma. AJNR Am J Neuroradiol 17:555–559
Rodriguez KH, Vargas S, Robson C et al (2007) Pleomorphic adenoma of the parotid gland in children. Int J Pediatr Otorhinolaryngol 71:1717–1723
Walterhouse DO, Pappo AS, Baker KS et al (2001) Rhabdomyosarcoma of the parotid region occurring in childhood and adolescence. A report from the Intergroup Rhabdomyosarcoma Study Group. Cancer 92:3135–3146
Geltzeiler M, Li G, Abraham J, Keller C (2015) The case for primary salivary rhabdomyosarcoma. Front Oncol 5:74
Renick B, Clark RM, Feldman L (1988) Embryonal rhabdomyosarcoma: presentation as a parotid gland mass. Oral Surg Oral Med Oral Pathol 65:575–579
Kralik SF, Haider KM, Lobo RR et al (2018) Orbital infantile hemangioma and rhabdomyosarcoma in children: differentiation using diffusion-weighted magnetic resonance imaging. J AAPOS 22:27–31
Freling NJM, Merks JH, Saeed P et al (2010) Imaging findings in craniofacial childhood rhabdomyosarcoma. Pediatr Radiol 40:1723–1738
Sultan I, Rodriguez-Galindo C, Al-Sharabati S et al (2011) Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases. Head Neck 33:1476–1481
Loy TS, McLaughlin R, Odom LF, Dehner LP (1989) Mucoepidermoid carcinoma of the parotid as a second malignant neoplasm in children. Cancer 64:2174–2177
Kashiwagi N, Dote K, Kawano K et al (2012) MRI findings of mucoepidermoid carcinoma of the parotid gland: correlation with pathological features. Br J Radiol 85:709–713
Christe A, Waldherr C, Hallett R et al (2011) MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol 32:1202–1207
Choi J, Choi HJ, Yim K et al (2018) Pediatric follicular lymphoma of the parotid gland. Arch Craniofac Surg 19:279–282
Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS (2009) Acinic cell carcinoma of the salivary glands: a literature review. Hematol Oncol Stem Cell Ther 2:259–264
Sepúlveda I, Frelinghuysen M, Platin E et al (2015) Acinic cell carcinoma of the parotid gland: a case report and review of the literature. Case Rep Oncol 8:1–8
Gaunt T, D’Arco F, Smets AM et al (2019) Emergency imaging in paediatric oncology: a pictorial review. Insights Imaging 10:120
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
None
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
D’Arco, F., Ugga, L. Computed tomography and magnetic resonance imaging in pediatric salivary gland diseases: a guide to the differential diagnosis. Pediatr Radiol 50, 1293–1307 (2020). https://doi.org/10.1007/s00247-020-04684-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-020-04684-3