Abstract
This is the first report specifically describing outcomes of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation. One hundred forty-four cardiac catheterizations were identified that met inclusion criteria at our institution from 11/2014 to 10/2019. The median age and weight of the patients were 6.3 [0.01–20.9] years and 19.3 [2.1–172.5] kg, respectively. Seventy-eight (54%) catheterizations involved inpatients. The most common cardiac diagnoses among the cohort were single ventricle (n = 41), conotruncal defects (n = 37), and structurally normal heart (n = 16). The most common indications for anticoagulation were arterial/venous thrombus (n = 45), Fontan physiology (n = 32), and mechanical valve thrombus prophylaxis (n = 27). The anticoagulation medications used were warfarin (n = 57), heparin (n = 52), enoxaparin (n = 25), fondaparinux (n = 5), rivaroxaban (n = 2), and both heparin and warfarin (n = 3). Interventions were performed in 96 cases (67%). The median length of the procedure was 122.5 [15–760] minutes, and the median time to achieve hemostasis was 18.0 [range: 5–76, IQR: 13–25] minutes. Adverse events were present in 11 cases (7.6%), and of those only 2 cases (1.4%) were bleeding-related complications. Our single-center data suggest that performing cardiac catheterization on pediatric patients while on uninterrupted anticoagulation is safe and does not substantially increase the risk of bleeding complications based on a cohort of patients that varied in age, size, diagnosis, medical complexity, and type of intervention performed. Patients on warfarin therapy for a mechanical valve are most likely to benefit from this practice, as the ability to continue warfarin therapy avoids the need for bridging and other interruption-related complications.
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Introduction
Anticoagulation is often held in pediatric patients undergoing cardiac catheterization based on adult guidelines and practices. In adults, oral anticoagulation agents are held (with or without heparin bridging) prior to cardiac catheterization due to concerns for potential bleeding complications [1, 2]. For femoral access, a recent consensus statement on best practices in the cardiac catheterization laboratory recommends holding warfarin until the international normalized ratio (INR) falls below 1.8 and holding direct oral anticoagulant (DOAC) therapy for a minimum of 24–48 h based on the operator’s perception of bleeding risk [3]. However, evidence in adults has shown that cardiac catheterization-related bleeding risk is similar in uninterrupted vitamin K antagonist (VKA) therapy compared to interrupted therapy, and uninterrupted VKA therapy has a lower risk of bleeding compared to interrupted VKA therapy with heparin bridging [4,5,6]. Similar findings have been demonstrated regarding hematoma formation between uninterrupted versus interrupted DOAC therapy prior to pacemaker or defibrillator implantation and prior to catheter ablation in atrial fibrillation [7,8,9].
In children undergoing cardiac catheterization, the incidence of bleeding or hematoma has been shown to be low at 0.6–0.8% [10, 11]. However, studies regarding the safety of performing a cardiac catheterization while on systemic anticoagulation are lacking. A survey conducted in 2018 demonstrated significant variation in preoperative antiplatelet agent and intraoperative anticoagulation practices among providers performing cardiac catheterization in children and adults with congenital heart disease [12]. Although the study only assessed practices regarding aspirin, clopidogrel, and intraprocedural heparin, it is likely that variability also exists in pre-procedural anticoagulation practices involving other systemic anticoagulation agents. At our heart center, we typically do not hold anticoagulation prior to cardiac catheterization. Here, we report our outcomes in a cohort of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation.
Materials and Methods
This was a retrospective study performed with Institutional Review Board approval (protocol number CHLA-19-00456). Patients who were treated with systemic anticoagulation and underwent cardiac catheterization from 11/2014 to 10/2019 at our institution were identified using institutional databases and retrospectively reviewed. Exclusion criteria included interruption of systemic anticoagulation prior to cardiac catheterization and individuals on aspirin monotherapy.
Data collected included patient demographics, cardiac diagnosis, date of last cardiac surgery, indication for anticoagulation, type of anticoagulation used, whether arterial or venous access was utilized, largest sheath size, use of ultrasound for vascular access, interventions performed, preoperative and intraoperative labs, hemostasis method and time, and adverse events. For patients that received manual pressure for hemostasis, times were estimated by time stamps for sheath removal and dressing placement in the electronic medical record. Adverse events were classified as minor, moderate, major, or catastrophic according to previously published and tested definitions [13].
Statistical Analysis
Continuous variables are presented as median [range] as they were not normally distributed. The statistical analysis was done with JMP Pro 15.1 (SAS institute Inc., Cary, NC) and Microsoft Excel 16.16.10.
Results
One hundred fifty-one cardiac catheterizations were identified in 111 patients from 11/2014 to 10/2019 who were being treated with anticoagulation. Seven cases were excluded because anticoagulation was held prior to catheterization. The median age and weight of the remaining patients were 6.3 [0.01–20.9] years and 19.3 [2.1–172.5] kg, respectively (Table 1). Seventy-eight (54%) catheterizations involved inpatients. The most common cardiac diagnoses among the cohort were single ventricle (n = 41), conotruncal defects (n = 37), and structurally normal heart (n = 16) (Table 1).
Indication for Anticoagulation and Anticoagulation Levels
The most common indications for anticoagulation were arterial or venous thrombosis (n = 45), Fontan physiology including primary prophylaxis, fenestration, or thrombus (n = 32), mechanical valve (AV valve n = 23, aortic valve n = 4), extracorporeal membrane oxygenation (ECMO, n = 16), heart failure (n = 9), and coronary artery aneurysm (n = 8) (Table 2). The anticoagulation medications used were warfarin (n = 57), heparin (n = 52), enoxaparin (n = 25), fondaparinux (n = 5), rivaroxaban (n = 2), and both heparin and warfarin (n = 3). Fifty-three patients were on antiplatelet agents in addition to systemic anticoagulation (Table 1). Pre-catheterization INR was available in 58 patients on warfarin and the median was 2.35 [1.4–6.6] (Table 3). Pre-catheterization anti-Xa was available in 43 patients on heparin infusion and 21 patients on enoxaparin; the medians were 0.41U/ml [0.05–1.96] and 0.63 [0.23–1], respectively.
Procedural Characteristics
Ultrasound was utilized for vascular access in 78 cases (54%) (Table 3). Both arterial and venous access were obtained in 95 cases (66%), only arterial access in 8 cases (6%), and only venous access in 41 cases (29%). The largest arterial access obtained was a 7 Fr sheath in 1 case. The most commonly used sheath sizes for arterial access were a 4 Fr sheath in 50 cases, 5 Fr sheath in 29 cases, 3.3 Fr sheath in 7 cases, and a 20 G arterial catheter or a dilator from a 4 Fr micro-introducer kit in 16 cases. The largest venous sheath was 22 Fr, and a sheath larger than 7 Fr was used in 32 cases. The opening activated clotting time was 184 [77–308] seconds (n = 101). Additional anticoagulation was administered during catheterization in 92 cases, including heparin in 87 cases and bivalirudin in 5 cases. The median bolus doses of heparin and bivalirudin given were 72 units/kg [17.5–101.9 units/kg] and 0.5 mg/kg [0.45–0.50 mg/kg)], respectively.
Interventions or special diagnostic procedures (endomyocardial or liver biopsy) (n = 159) were common and performed in 96 cases (67%) (Table 4). They included angioplasty (n = 67), stent implantation (n = 31), vascular embolization (n = 18), transeptal puncture (n = 10), transjugular liver biopsy (n = 10), thrombectomy (n = 11), Fontan fenestration occlusion (n = 6), endomyocardial biopsy (n = 3), valvuloplasty (n = 2), and balloon atrial septostomy (n = 1). The median length of the procedure was 122.5 [15–760] minutes, and the median time to achieve hemostasis for cases that received manual pressure was 18.0 [range: 5–76, IQR: 13–25] minutes.
Adverse Events and Hematologic Complications
Adverse events were present in 11 cases (7.6%). There were six minor (4.2%) events (transient arrhythmia in three, bleeding from access site on the day following catheterization, small hematoma, and sheath dislodgement). There was one moderate (0.7%) event (non-occlusive arterial thrombus). There were four major (2.8%) events (ventricular fibrillation, transient complete heart block, and respiratory arrest in two). Bleeding complications were present in two cases (1.4%), both of which were classified as minor. Both patients were on warfarin as the anticoagulation agent with INRs of 2.8 and 3.1.
Discussion
This is the first report specifically describing outcomes of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation. Our single-center data suggest that this practice is safe and does not substantially increase the risk of bleeding complications in a cohort of patients that varied in age, size, diagnosis, and type of intervention performed. The most common indications for anticoagulation were venous or arterial thrombosis, Fontan physiology, and mechanical valve thrombus prophylaxis. Patients were most likely to be on warfarin (39.6%) or heparin (36.1%) for anticoagulation.
Patients on warfarin therapy for a mechanical valve are most likely to benefit from this practice, as interruption of warfarin therapy is not ideal. The ability to continue warfarin therapy avoids the need for bridging, a period without anticoagulation therapy, as well as the need to transition the patient back to warfarin therapy. This practice can help to minimize the number of lab draws and length of hospital stay, particularly in young infants where management of warfarin can be challenging. In adults this has been shown to be a safer practice in patients undergoing pacemaker or defibrillator implantation with lower rates of device-pocket hematoma in the group that did not have interruption of warfarin therapy [14]. Furthermore, it has also been shown to be safe in adults undergoing diagnostic cardiac catheterization via the femoral or radial arteries and coronary interventions via the radial artery [6].
Hemostasis
One of the outcome measures of this study was time to hemostasis. The median time to hemostasis in all catheterizations using manual pressure was 18.0 [range: 5–76, IQR: 13–25] minutes, with 62% requiring more than 15 min of compression. Waragai et al. published a study assessing hemostasis times in pediatric patients, which demonstrated a mean time to hemostasis of 16.1 min, with 36% requiring more than 15 min of compression [15]. Our cohort did not differ substantially from this. Data in adults support this finding as well. Lippe et al. demonstrated that hemostasis times are similar in adults undergoing radial artery catheterization whether or not they were on uninterrupted warfarin [16].
Complications
Overall complication rates (7.6%) seen in this study are consistent with previously published rates which have ranged from 7.3 to 15% [10, 11, 17]. When specifically analyzing bleeding complications our cohort had a similar rate (1.4%) of complications when compared to Mehta et al. (0.7%) and Vitiello et al. (0.8%) [10, 11]. None of the bleeding complications in our cohort were classified as major compared to the 4.1% and 11.9% classified as such by Mehta et al. and Vitiello et al., respectively. In comparing our cohort to the aforementioned published cohorts, it is important to note that our patients were, on average, suffering from more severe illness with over half requiring inpatient care and over 10% requiring ECMO.
While we were able to show the complications are relatively minor and rare while performing a variety of transcatheter interventions, it is important to tailor the anticoagulation plan to the patient. The diagnosis, indication for anticoagulation, bleeding risk of the planned intervention, access site, and anticipate sheath sizes should all be considered. Additionally, it is important to assess the activated clotting time and modify the intraprocedural anticoagulation dose if necessary [18]. In our population we either omitted or modified the intraprocedural anticoagulation dose. Another procedural modification that can be considered is use of a suture-mediated closure device, particularly in obese patients in whom bleeding or hematoma development may be more difficult to immediately recognize.
Limitations
There were several limitations to our study. This is a retrospective study with data from a single center with a relatively small sample size. The patient cohort is heterogenous with a variety of diagnoses, indications for anticoagulation, anticoagulation therapies, and therapeutic goals. Additionally, there was no control group to compare the cohort’s outcomes to. Despite these limitations, there are several important observations that can be made from this study.
Conclusion
This study demonstrates cardiac catheterization with a variety of interventions and utilizing a range of arterial and venous sheaths may be performed safely in pediatric patients on uninterrupted anticoagulation. Bleeding-related complications were similar to previously reported rates in patients not on anticoagulation, and observed complications were all mild in nature. Further studies in a larger cohort of patients are needed to better characterize the effects of uninterrupted vs interrupted anticoagulation in pediatric patients undergoing cardiac catheterization.
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R and P conceptualized and designed the project, collected the patient data, drafted the initial manuscript, and reviewed and revised the manuscript. B conceptualized and designed the project, revised aspects of the data presented, and critically reviewed and revised the manuscript. S and T revised aspects of the data presented and critically reviewed and revised the manuscript. All authors approve the final manuscript as submitted and agree to be accountable for all aspects of the work.
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This was a retrospective study performed with Institutional Review Board approval (protocol number CHLA-19-00456).
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Rao, M.Y., Sullivan, P.M., Takao, C. et al. Safety of Continuing Anticoagulation Prior to Cardiac Catheterization in Pediatric Patients: A Los Angeles Center Experience. Pediatr Cardiol 44, 1009–1013 (2023). https://doi.org/10.1007/s00246-023-03097-x
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DOI: https://doi.org/10.1007/s00246-023-03097-x