Abstract
The epidemiologic data for pediatric hypertrophic cardiomyopathy (HCM) needs to be periodically updated as diagnostic techniques and management strategies improve. Herein, the incidence, prevalence, and mortality rates of pediatric HCM in a population-based treatment system are described. Patients aged ≤ 17 years and diagnosed with HCM on service visits over a 10-year period in one state Medicaid database (2007–2016) were analyzed. The cohort included 137 unique patients; 64.2% were male; 40.9% were African American; 42.3% were first diagnosed ≤ 24 months. The accrued 10-year prevalence rate for pediatric HCM was 1.2/1,000,000 and the annual incidence rate (CY 2010) was 1.3/100,000. Cardiac-related mortality was 2.9% in those who died cohort (N = 10); 70.0% of those who died were ≤ 13 months of age. Arrhythmia was diagnosed in 30.7% of the cohort, heart failure in 12.4%, and low birth weight in 8.8%. Inborn errors of metabolism were diagnosed in 8.0% of the cohort; malformation syndromes in 13.1%, and neuromuscular disorders in 2.9%; therefore, 75.9% were classified as idiopathic HCM. Our findings are somewhat higher than extant study estimates but update and augment them in representing a Southeast US statewide service system.
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This dataset was provided to Dr. Jerrell, as Principal Investigator, for specific analyses and is not publicly available.
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The views expressed do not necessarily represent official findings of the South Carolina Department of Health and Human Services (Medicaid).
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JMJ, YW: had full control over the data and the analyses performed and assume full responsibility for the results presented. DN, EAH contributed to the conception and design of the study, interpretation of the results, and drafting of the manuscript. All authors provided critical review and revisions to the final manuscript.
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Nandi, D., Hayes, E.A., Wang, Y. et al. Epidemiology of Pediatric Hypertrophic Cardiomyopathy in a 10-Year Medicaid Cohort. Pediatr Cardiol 42, 210–214 (2021). https://doi.org/10.1007/s00246-020-02472-2
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DOI: https://doi.org/10.1007/s00246-020-02472-2