Skip to main content

Advertisement

SpringerLink
Log in

A Survey of Dietary Intake of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like Coplanar Polychlorinated Biphenyls from Food During 2000–2002 in Osaka City, Japan

  • Published:
Archives of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

Studies of the dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like coplanar polychlorinated biphenyls (dioxin-like PCBs), collectively referred as dioxins, were conducted using the total diet study (TDS) method with food purchased in Osaka City, Japan during 2000–2002. The daily intake of dioxin-TEQ (toxic equivalent) from food per adult person was estimated respectively as 104.24 pg TEQ/person/day in 2000, 72.73 pg TEQ/person/day in 2001, and 87.28 pg TEQ/person/day in 2002, corresponding to 2.08, 1.45, and 1.74 pg TEQ/kg body weight (bw)/day for an adult weighing 50 kg. The highest contribution ratio to the total intake of dioxin-TEQ was from fish and shellfish (group 10) in each year, accounting for 77–92%. The next highest contributor was meat and eggs (groups 11-A and 11-B). An annual decrease of the intake of dioxin-TEQ was not observed clearly. Otherwise, the dietary intake of non-2,3,7,8-substituted PCDDs/PCDFs were estimated together. The intake of 1,3,6,8-TeCDD came mostly from intake of fish and shellfish (group 10), green vegetable (group 7), and the other vegetables, including mushrooms and seaweed (group 8). In addition, the intake of 1,3,6,8-TeCDF, which reportedly antagonizes 2,3,7,8-TeCDD-mediated aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD) induction activities, was an insufficient amount to suppress 2,3,7,8-TeCDD-mediated activities. Furthermore, we discussed different TEQ compositions of PCDDs/PCDFs to dioxin-like PCBs from food intake and in human samples and inferred that the difference was caused by low bioaccumulation properties of 3,3′,4,4′,5-PeCB (PCB 126).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Akutsu K, Kuwabara K, Konishi Y, Matsumoto H, Murakami Y, Tanaka Y, Matsuda R, Hori S (2005) Congener-specific analysis of PCBs in food samples by using GC/MS. J Food Hyg Soc Jpn 46:99–108 (in Japanese)

    Article  CAS  Google Scholar 

  • Chen PH, Luo ML, Wong CK, Chen CJ (1982) Comparative rates of elimination of some individual polychlorinated biphenyls from the blood of PCB-poisoned patients in Taiwan. Food Chem Toxicol 20:417–425

    Article  CAS  Google Scholar 

  • Davis D, Safe S (1988) Immunosuppressive activities of polychlorinated dibenzofuran congeners: quantitative structure activity relationships interactive effects. Toxicol Appl Pharmacol 94:141–149

    Article  CAS  Google Scholar 

  • EU SCF (European Scientific Committee on Food) (2001) Opinion of the SCF on the risk assessment of dioxins and dioxin-like PCBs in food. European Commission, Brussels. Update based on new scientific information available since the adoption of the SCF opinion of 22 November 2000. Adopted on 30 May 2001. Available from http://europa.eu.int/comm/food/fs/sc/scf/out90_en.pdf

  • Feeley M, Brouwer A (2000) Health risks to infants from exposure to PCBs, PCDDs and PCDFs. Food Addit Contam 17:325–333

    Article  CAS  Google Scholar 

  • Focant J-F, Eppe G, Pirard C, Massart A-C, Andre J-E, De Pauw E (2002) Levels and congener distributions of PCDDs, PCDFs and non-ortho PCBs in Belgian foodstuffs: assessment of dietary intake. Chemosphere 48:167–179

    Article  CAS  Google Scholar 

  • Fraser CA, Gardner GJ, Maxwell PS, Kubwabo C, Guevremont R, Siu KWM, Berman SS (1995) Preparation and certification of a biological reference material (CARP-1) for polychlorinated dibenzo-p-dioxin and dibenzofuran congeners. Fresenius J Anal Chem 352:143–147

    Article  CAS  Google Scholar 

  • Freijer JI, Hoogerbrugge R, van Klaveren JD, Traag WA, Hoogenboom LAP, Liem AKD (2001) Dioxins and dioxin-like PCBs in foodstuffs: occurrence and dietary intake in The Netherlands at the end of the 20th century. RIVM report 639102022, Bilthoven, The Netherlands

  • Guan P, Tajimi M, Uehara R, Watanabe M, Oki I, Ojima T, Nakamura Y (2006) Congener profiles of PCDDs, PCDFs, and dioxin-like PCBs in breast milk samples in Tokyo, Japan. Chemosphere 62:1161–1166

    Article  CAS  Google Scholar 

  • Horii S, Sasamoto T, Otaka H (2003) Improved analytical method for residual dioxins in human milk. Bull Environ Contam Toxicol 70:1121–1127

    Article  CAS  Google Scholar 

  • Hsu MS, Hsu KY, Wang SM, Chou U, Chen SY, Huang NC, Liao CY, Yu TP, Ling YC (2007) A total diet study to estimate PCDD/Fs and dioxin-like PCBs intake from food in Taiwan. Chemosphere 67:S65–S70

    Article  CAS  Google Scholar 

  • JECFA (Joint FAO/WHO Expert Committee on Food Additives) (2001) Summary of the fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives, Rome, 5–14 June 2001, pp 24–40. Available from http://www.fao.org/es/ESN/Jecfa/57corr.pdf

  • Kalantzi OI, Alcock RE, Johnston PA, Santillo D, Stringer RL, Thomas GO, Jones KC (2001) The global distribution of PCBs and organochlorine pesticides in butter. Environ Sci Technol 35:1013–1018

    Article  CAS  Google Scholar 

  • Keys B, Piskorska-Pliszczynska J, Safe S (1986) Polychlorinated dibenzofurans as 2,3,7,8-TCDD antagonists: in vitro inhibition of monooxygenase induction. Toxicol Lett 31:151–158

    Article  CAS  Google Scholar 

  • Kim H, Chung S, Sho Y, Suh J, Park S, Lee E, Lee Y, Jang S, Ha J (2005) A survey of PCDD/Fs and dioxin-like PCBs in Korea retail food from 2002–2004. Organohalogen Compd 67:1484–1487

    Google Scholar 

  • Kiviranta H, Ovaskainen M-L, Vartiainen T (2004) Market basket study on dietary intake of PCDD/Fs, PCBs and PBDEs in Finland. Environ Int 30:923–932

    Article  CAS  Google Scholar 

  • Lorber M, Cleverly D, Schaum J, Phillips L, Schweer G, Leighton T (1994) Development and validation of air-beef food chain model for dioxin-like compounds. Sci Total Environ 156:39–65

    Article  CAS  Google Scholar 

  • McLachlan MS (1997) A simple model to predict accumulations of PCDD/Fs in an agricultural food chain. Chemosphere 34:1263–1276

    Article  CAS  Google Scholar 

  • Mimura K, Tamura M, Haraguchi K, Masuda Y (1999) Analysis of all PCB congeners in breast milk and blood of Yusho patients. Fukuoka Acta Med 90:202–209 (in Japanese)

    CAS  Google Scholar 

  • Ministry of the Environmental, Government of Japan (2004) Dioxin Emission Inventory, Office of Ministry of the Environmental, Government of Japan, Tokyo

  • Müller JF, Prange J, Gaus C, Moore MR, Päpke O (2001) Dioxin-like compounds in butter from Australia. Organohalogen Compd 51:380–383

    Google Scholar 

  • Naito W, Jin J, Kang Y-S, Yamamuro M, Masunaga S, Nakanishi J (2003) Dynamics of PCDDs/DFs and coplanar-PCBs in an aquatic food chain of Tokyo Bay. Chemosphere 53:347–362

    Article  CAS  Google Scholar 

  • Nakai S, Hashimoto O, Yoshida K, Nakanishi J (2001) Estimation of half-lives of 2,3,7,8-chlorine substituted dioxins and furans and dioxin-like PCBs in humans. Organohalogen Compd 52:330–333

    Google Scholar 

  • Nakatani T, Itano K, Fujita T (2005a) Contamination levels of PCDDs, PCDFs and CoPCBs in fish oils and used as raw materials for margarine and shortening retailed fish. J Food Hyg Soc Jpn 46:169–175

    Article  CAS  Google Scholar 

  • Nakatani T, Okazaki K, Ogaki S, Itano K, Fujita T, Kuroda K, Endo G (2005b) Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in human milk in Osaka City, Japan. Arch Environ Contam Toxicol 49:131–140

    Article  CAS  Google Scholar 

  • Nakatani T, Ogaki S, Itano K, Fujita T, Mori Y, Endo G (2006) Toxic equivalent (TEQ) levels and characteristics of PCDD/DF and CoPCB concentrations in marine foods in Japan. Bull Environ Contam Toxicol 77:237–244

    Article  CAS  Google Scholar 

  • Ogura I, Masunaga S, Nakanishi J (2001) Congener-specific characterization of PCDDs/PCDFs in atmospheric deposition: comparison of profiles among deposition, source, and environmental sink. Chemosphere 45:173–183

    Article  CAS  Google Scholar 

  • Ryan JJ, Levesque D, Panopio LG, Sun WF, Masuda Y, Kuroki H (1993) Elimination of polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) from human blood in the Yusho and Yu-Cheng rice oil poisonings. Arch Environ Contam Toxicol 24:504–512

    Article  CAS  Google Scholar 

  • Safe S (1990) Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21:51–88

    Article  CAS  Google Scholar 

  • Santillo D, Fernandes A, Stringer R, Johnston P, Rose M, White S (2001) Concentrations of PCDDs, PCDFs and PCBs in samples of butter from 24 countries. Organohalogen Compd 51:275–278

    CAS  Google Scholar 

  • Sasamoto T, Ushio F, Kikutani N, Saitoh Y, Yamaki Y, Hashimoto T, Horii S, Nakagawa J, Ibe A (2006) Estimation of 1999–2004 dietary daily intake of PCDDs, PCDFs and dioxin-like PCBs by a total diet study in metropolitan Tokyo, Japan. Chemosphere 64:634–641

    Article  CAS  Google Scholar 

  • Swerev M, Ballschmiter K (1989) Pattern analysis of PCDDs and PCDFs in environmental samples as an approach to an occurrence/source correlation. Chemosphere 18:609–616

    Article  Google Scholar 

  • Tanabe S, Kannan N, Wakimoto T, Tatsukawa R (1989) Isomer-specific determination and toxic evaluation of potentially hazardous coplanar PCBs, dibenzofurans and dioxins in the tissues of “Yusho” PCB poisoning victim in the causal oil. Toxicol Environ Chem 24:215–231

    Article  CAS  Google Scholar 

  • Thomas GO, Sweetman AJ, Lohmann R, Jones KC (1998) Derivation and field testing of air-milk and feed-milk transfer factor for PCBs. Environ Sci Technol 32:3522–3528

    Article  CAS  Google Scholar 

  • Toyoda M, Uchibe H, Yanagi T, Kono Y, Hori T, Iida T (1999) Dietary daily intake of PCDDs, PCDFs and coplanar PCBs by total diet study in Japan. J Food Hyg Soc Jpn 40:98–110

    CAS  Google Scholar 

  • Tsutsumi T, Amakura Y, Sasaki K, Toyoda M, Maitani T (2003) Evaluation of an aqueous KOH digestion followed by hexane extraction for analysis of PCDD/Fs and dioxin-like PCBs in retailed fish. Anal Bioanal Chem 375:792–798

    CAS  Google Scholar 

  • Tsutsumi T, Yanagi T, Nakamura M, Kono Y, Uchibe H, Iida T, Hori T, Nakagawa R, Tobiishi K, Matsuda R, Sakai K, Toyoda M (2001) Update of daily intake of PCDDs, PCDFs and dioxin-like PCBs from food in Japan. Chemosphere 45:1129–1137

    Article  CAS  Google Scholar 

  • Tuinstra LGMT, Startin JR, Maier EA, Kramer GN (1997) Certification of the contents of five polychlorodibenzo-p-dioxins and six polychlorodibenzo furans in milk powder. Fresenius J Anal Chem 359:222–229

    Article  CAS  Google Scholar 

  • Uehara R, Guan P, Nakamura Y, Matsuura N, Kondo N, Tada H (2006) Human milk survey for dioxins in the general population in Japan. Chemosphere 62:1135–1141

    Article  CAS  Google Scholar 

  • Van den Berg M, Birnbaum L, Bosveld ATC, Brunstrom B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, Van Leeuwen FXR, Liem AKD, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Waern F, Zacharewski T (1998) Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775–792

    Google Scholar 

  • Wehrmeier A, Lenoir D, Schramm KW, Zimmermann R, Hahn K, Henkelmann B, Kettrup A (1998) Patterns of isomers of chlorinated dibenzo-p-dioxins as tool for elucidation of thermal formation mechanisms. Chemosphere 36:2775–2801

    Article  CAS  Google Scholar 

Download references

Acknowledgment

The authors thank all who conducted and participated in supporting the production of TDS samples.

Author information

Authors and Affiliations

  1. Department of Food and Health Science, Osaka City Institute of Public Health and Environmental Science, 8-34, Tohjo-cho, Tennoji-ku, Osaka, 543-0026, Japan

    Tadashi Nakatani, Atsushi Yamamoto & Sumiko Ogaki

Authors
  1. Tadashi Nakatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsushi Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sumiko Ogaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tadashi Nakatani.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakatani, T., Yamamoto, A. & Ogaki, S. A Survey of Dietary Intake of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like Coplanar Polychlorinated Biphenyls from Food During 2000–2002 in Osaka City, Japan. Arch Environ Contam Toxicol 60, 543–555 (2011). https://doi.org/10.1007/s00244-010-9553-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00244-010-9553-y

Keywords

Search

Navigation