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Drug release from matrix systems: analysis by finite element methods

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Abstract

In this work some problems in drug delivery from solid systems were described in terms of transient mass balances with diffusion and solved by using FEM. Firstly, the solving codes were compared with known analytical solutions, available for simple problems (simple geometries, constant diffusivities). Then, models were written to describe more realistic systems (complex geometries, variable diffusivities). Eventually, the behaviors of some real drug delivery systems were successfully predicted.

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Authors and Affiliations

  1. Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, via Ponte don Melillo, 84084, Fisciano, SA, Italy

    Ivan Galdi & Gaetano Lamberti

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  1. Ivan Galdi
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  2. Gaetano Lamberti
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Correspondence to Gaetano Lamberti.

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Galdi, I., Lamberti, G. Drug release from matrix systems: analysis by finite element methods. Heat Mass Transfer 48, 519–528 (2012). https://doi.org/10.1007/s00231-011-0900-y

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  • DOI: https://doi.org/10.1007/s00231-011-0900-y

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