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Ambient desorption/ionization mass spectrometry: evolution from rapid qualitative screening to accurate quantification tool

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Abstract

In this article, some recent trends and developments in ambient desorption/ionization mass spectrometry (ADI-MS) are reviewed, with a special focus on quantitative analyses with direct, open-air sampling. Accurate quantification with ADI-MS is still not routinely performed, but this aspect is considered of utmost importance for the advancement of the field. In fact, several research groups are devoted to the development of novel and optimized ADI-MS approaches. Some key trends include novel sample introduction strategies for improved reproducibility, tailored sample preparation protocols for removing the matrix and matrix effects, and multimode ionization sources. In addition, there is significant interest in quantitative mass spectrometry imaging.

Conceptual diagram of the ambient desorption/ionization mass spectrometry approach with different desorption/ionization probes

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180, USA

    Jacob T. Shelley & Sunil P. Badal

  2. Department of Chemistry and Biology, University of Siegen, Adolf-Reichwein-Straße 2, 57076, Siegen, Germany

    Carsten Engelhard

  3. Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 30, 48149, Münster, Germany

    Heiko Hayen

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  1. Jacob T. Shelley
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Shelley, J.T., Badal, S.P., Engelhard, C. et al. Ambient desorption/ionization mass spectrometry: evolution from rapid qualitative screening to accurate quantification tool. Anal Bioanal Chem 410, 4061–4076 (2018). https://doi.org/10.1007/s00216-018-1023-9

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