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Bipolar disorder: recent advances and future trends in bioanalytical developments for biomarker discovery

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Abstract

In this manuscript we briefly describe bipolar disorder (a depressive and manic mental disease), its classification, its effects on the patient, which sometimes include suicidal tendencies, and the drugs used for treatment. We also address the status quo with regard to diagnosis of bipolar disorder and recent advances in bioanalytical approaches for biomarker discovery. These approaches focus on blood samples (serum and plasma) and proteins as the main biomarker targets, and use various strategies for protein depletion. Strategies include use of commercially available kits or other homemade strategies and use of classical proteomics methods for protein identification based on “bottom-up” or “top-down” approaches, which used SELDI, ESI, or MALDI as sources for mass spectrometry, and up-to-date mass analyzers, for example Orbitrap. We also discuss some future objectives for treatment of this disorder and possible directions for the correct diagnosis of this still-unclear mental illness.

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Acknowledgments

The authors thank Fundação de Amparo as Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brasília, Brazil), and the Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior (CAPES, Brasília, Brazil) for financial support and fellowships.

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Authors and Affiliations

  1. Spectrometry, Sample Preparation and Mechanization Group – GEPAM, Institute of Chemistry, University of Campinas – UNICAMP, P.O. Box 6154, Campinas, SP, 13083-970, Brazil

    Jemmyson Romário de Jesus, Bruna Kauely de Campos, Rodrigo Moretto Galazzi & Marco Aurélio Zezzi Arruda

  2. National Institute of Science and Technology for Bioanalytics, Institute of Chemistry, University of Campinas – Unicamp, P.O. Box 6154, Campinas, SP, 13083-970, Brazil

    Jemmyson Romário de Jesus, Bruna Kauely de Campos, Rodrigo Moretto Galazzi & Marco Aurélio Zezzi Arruda

  3. REQUIMTE, Department of Chemistry, College of Science and Technology, Faculdade Nova de Lisboa, Caparica, 2829-516, Portugal

    José Luis Capelo Martinez

  4. ProteoMass Scientific Society, Madan Park, Rua dos Inventores s/n, Monte de Caparica, Caparica, 2829-516, Portugal

    José Luis Capelo Martinez

Authors
  1. Jemmyson Romário de Jesus
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  2. Bruna Kauely de Campos
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  3. Rodrigo Moretto Galazzi
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  4. José Luis Capelo Martinez
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  5. Marco Aurélio Zezzi Arruda
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Correspondence to Marco Aurélio Zezzi Arruda.

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Published in the topical collection celebrating ABCs 13th Anniversary.

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de Jesus, J.R., de Campos, B.K., Galazzi, R.M. et al. Bipolar disorder: recent advances and future trends in bioanalytical developments for biomarker discovery. Anal Bioanal Chem 407, 661–667 (2015). https://doi.org/10.1007/s00216-014-8341-3

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  • DOI: https://doi.org/10.1007/s00216-014-8341-3

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