Abstract
The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5–25 mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100 mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33 % protection at 50 and 100 mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25 mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property.
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Abbreviations
- GABAA :
-
Gamma aminobutyric acid
- HLE:
-
Hind limb extension
- ICT:
-
Institute of Chemical Technology
- IAEC:
-
Institutional Animals Ethics Committee
- MES:
-
Maximal electroshock
- MDA:
-
Malondialdehyde
- PTZ:
-
Pentylenetetrazole
- ROS:
-
Reactive oxygen species
- STR:
-
Strychnine
- 4-AP:
-
4-Aminopyridine
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The authors would like to thank to UGC-SAP for funding the research.
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Sancheti, J., Shaikh, M.F., Chaudhari, R. et al. Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models. Naunyn-Schmiedeberg's Arch Pharmacol 387, 59–66 (2014). https://doi.org/10.1007/s00210-013-0917-5
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DOI: https://doi.org/10.1007/s00210-013-0917-5