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Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

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Abstract

Resveratrol, a natural compound endowed with multiple health-promoting effects, has received much attention given its potential for the treatment of cardiovascular, inflammatory, neurodegenerative, metabolic and age-related diseases. However, the translational potential of resveratrol has been limited by its specificity, poor bioavailability and uncertain toxicity. In recent years, there has been an accumulation of evidence demonstrating that resveratrol modulates sphingolipid metabolism. Moreover, resveratrol forms higher order oligomers that exhibit better selectivity and potency in modulating sphingolipid metabolism. This review evaluates the evidence supporting the modulation of sphingolipid metabolism and signaling as a mechanism of action underlying the therapeutic efficacy of resveratrol and oligomers in diseases, such as cancer.

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  1. Keng Gat Lim

    Present address: Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research (A*STAR), Singapore, 138672, Singapore

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  1. Cell Biology and Drug Discovery and Design Groups, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK

    Keng Gat Lim, Alexander I. Gray, Nahoum G. Anthony, Simon P. Mackay, Susan Pyne & Nigel J. Pyne

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Lim, K.G., Gray, A.I., Anthony, N.G. et al. Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease. Arch Toxicol 88, 2213–2232 (2014). https://doi.org/10.1007/s00204-014-1386-4

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