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Bone mass loss is associated with systolic blood pressure in postmenopausal women with type 2 diabetes in Tibet: a retrospective cross-sectional study

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Abstract

Summary

We conducted an observational cross-section study to investigate the status of bone mineral mass of Tibetan postmenopausal women with type 2 diabetes and the possible predictors for osteoporosis. We found that prevalence of osteoporosis was 27.0% and blood pressure was an independent risk factor for bone mass loss.

Introduction

The aims of this study is to investigate the prevalence of osteoporosis in postmenopausal women with type 2 diabetes dwelling in Tibet and the possible risk factors for bone mass loss.

Methods

We recruited 99 Chinese Tibetan postmenopausal women with type 2 diabetes from the department of endocrinology of People’s Hospital Tibet Autonomous Region. Multiple sites of bone mineral density (BMD) were measured by dual-energy X-ray absorptiometry (DXA). The subjects were divided into three groups based on BMD T-score: osteoporosis, osteopenia, and normal. The clinical characteristics were compared between groups. The risk factors for bone mass loss were assessed by multiple linear regression analysis.

Results

Among diabetic postmenopausal women dwelling in high altitude, mean age was 62 ± 8 years, the median postmenopausal period was 12 years (5, 20), the median duration of diabetes mellitus was 3 years (1, 8), and mean BMI was 27.6 ± 4.2 kg/m2. Patients (52.5%) had hypertension. The percentages of patients with osteoporosis, osteopenia and normal BMD were 27.3, 42.4, and 30.3%, respectively. HbA1c and systolic blood pressure (SBP) were independently associated with T-scores of spine; ages and SBP were independently associated with T-scores of femoral neck or hip.

Conclusions

Among diabetic postmenopausal women dwelling in high altitude, 27.3% patients have osteoporosis, 42.4% patients have osteopenia, and 30.3% are normal. The BMD T-score of spine was inversely associated with SBP and positively associated with HbA1c, while the BMD T-score of femoral neck or hip was inversely associated with ages and SBP.

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References

  1. NIH Consensus Development Panel on Osteoporosis Prevention D, Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285:785–795

    Article  Google Scholar 

  2. Norsang G, Ma L, Dahlback A, Zhuoma C, Tsoja W, Porojnicu A, Lagunova Z, Moan J (2009) The vitamin D status among Tibetans. Photochem Photobiol 85:1028–1031

    Article  CAS  PubMed  Google Scholar 

  3. Lankford HV (2014) Extreme altitude: words from on high. Wilderness Environ Med 25:346–351

    Article  PubMed  Google Scholar 

  4. Basu M, Malhotra AS, Pal K, Chatterjee T, Ghosh D, Haldar K, Verma SK, Kumar S, Sharma YK, Sawhney RC (2013) Determination of bone mass using multisite quantitative ultrasound and biochemical markers of bone turnover during residency at extreme altitude: a longitudinal study. High Alt Med Biol 14:150–154

    Article  CAS  PubMed  Google Scholar 

  5. Seibel MJ, Cooper MS, Zhou H (2013) Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives. Lancet Diabetes Endocrinol 1:59–70

    Article  CAS  PubMed  Google Scholar 

  6. Tuchendler D, Bolanowski M (2014) The influence of thyroid dysfunction on bone metabolism. Thyroid Res 7:12

    Article  PubMed  PubMed Central  Google Scholar 

  7. Leidig-Bruckner G, Ziegler R (2001) Diabetes mellitus a risk for osteoporosis? Exp Clin Endocrinol Diabetes 109(Suppl 2):S493–S514

    Article  CAS  PubMed  Google Scholar 

  8. Ma L, Oei L, Jiang L, Estrada K, Chen H, Wang Z, Yu Q, Zillikens MC, Gao X, Rivadeneira F (2012) Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. Eur J Epidemiol 27:319–332

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Qorbani M, Bazrafshan HR, Aghaei M, Dashti HS, Rezapour A, Asayesh H, Mohammadi R, Mohammadi Y, Ansari H, Mansourian M (2013) Diabetes mellitus, thyroid dysfunctions and osteoporosis: is there an association? J Diabetes Metab Dis 12:38

    Article  Google Scholar 

  10. Rakel A, Sheehy O, Rahme E, LeLorier J (2008) Osteoporosis among patients with type 1 and type 2 diabetes. Diabetes Metab 34:193–205

    Article  CAS  PubMed  Google Scholar 

  11. Lo SS (2015) Bone health status of postmenopausal Chinese women. Hong Kong Med J 21:536–541

    PubMed  Google Scholar 

  12. Wang Y, Tao Y, Hyman ME, Li J, Chen Y (2009) Osteoporosis in China. Osteoporos Int 20:1651–1662

    Article  CAS  PubMed  Google Scholar 

  13. Haussler B, Gothe H, Gol D, Glaeske G, Pientka L, Felsenberg D (2007) Epidemiology, treatment and costs of osteoporosis in Germany—the BoneEVA study. Osteoporos Int 18:77–84

    Article  CAS  PubMed  Google Scholar 

  14. Petousi N, Robbins PA (2014) Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era. J Appl Physiol (1985) 116:875–884

  15. Ranhotra HS, Sharma R (2010) Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya. Indian J Clin Biochem 25:51–56

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Polly P, Tan TC (2014) The role of vitamin D in skeletal and cardiac muscle function. Front Physiol 5:145

    Article  PubMed  PubMed Central  Google Scholar 

  17. Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R, National Osteoporosis F (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 25:2359–2381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Rooze S, Dramaix-Wilmet M, Mathieu F, Bally P, Yangzom D, Li JZ, Goyens P (2012) Growth, nutritional status, and signs of rickets in 0-5-year-old children in a Kashin-Beck disease endemic area of Central Tibet. Eur J Pediatr 171:1185–1191

    Article  PubMed  Google Scholar 

  19. Starup-Linde J, Vestergaard P (2015) Management of endocrine disease: diabetes and osteoporosis: cause for concern? Eur J Endocrinol 173:R93–R99

    Article  CAS  PubMed  Google Scholar 

  20. Afghani A, Johnson CA (2006) Resting blood pressure and bone mineral content are inversely related in overweight and obese Hispanic women. Am J Hypertens 19:286–292

    Article  PubMed  Google Scholar 

  21. Cappuccio FP, Meilahn E, Zmuda JM, Cauley JA (1999) High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet 354:971–975

    Article  CAS  PubMed  Google Scholar 

  22. Park JS, Choi SB, Rhee Y, Chung JW, Choi EY, Kim DW (2015) Parathyroid hormone, calcium, and sodium bridging between osteoporosis and hypertension in postmenopausal Korean women. Calcif Tissue Int 96:417–429

    Article  CAS  PubMed  Google Scholar 

  23. Zhang J, Zhang K, Shi H, Tang Z (2015) A cross-sectional study to evaluate the associations between hypertension and osteoporosis in Chinese postmenopausal women. Int J Clin Exp Med 8:21194–21200

    PubMed  PubMed Central  Google Scholar 

  24. Yazici S, Yazici M, Korkmaz U, Engin Erkan M, Erdem Baki A, Erden I, Ozhan H, Ataoglu S (2011) Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women. Arch Med Sci 7:264–270

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by the Special Scientific Research Fund of Public Welfare Profession of China (201402005) and the Special Scientific Research Fund of Clinical Medicine of Chinese Medical Association (15010010589).

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Peking University of People’s Hospital, Beijing, China

    L. Zhou

  2. Department of Endocrinology, People’s Hospital of Tibet Autonomous Region, Lhasa, Tibet, China

    J. Song, S. Yang, S. Meng, X. Lv, J. Yue, A. Mina, B. Puchi, Y. Geng & L. Yang

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  1. L. Zhou
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  2. J. Song
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  3. S. Yang
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  4. S. Meng
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  5. X. Lv
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  6. J. Yue
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  7. A. Mina
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  8. B. Puchi
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  9. Y. Geng
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  10. L. Yang
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Corresponding author

Correspondence to L. Yang.

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Ethics statement

The study was approved by the Institutional ethnic committee of People’s Hospital of Tibet Autonomous Region.

Conflicts of interest

None.

Additional information

L. Zhou and J. Song contributed equally to this work.

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Zhou, L., Song, J., Yang, S. et al. Bone mass loss is associated with systolic blood pressure in postmenopausal women with type 2 diabetes in Tibet: a retrospective cross-sectional study. Osteoporos Int 28, 1693–1698 (2017). https://doi.org/10.1007/s00198-017-3930-6

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  • DOI: https://doi.org/10.1007/s00198-017-3930-6

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