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The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club

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Abstract

The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis.

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Authors and Affiliations

  1. Department of Clinical Chemistry, UnilabLg, CIRM, University of Liège, CHU de Liège, Domaine du Sart-Tilman, 4000, Liège, Belgium

    E. Cavalier

  2. Department of Radioisotopes, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium

    P. Bergmann

  3. Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium

    O. Bruyère

  4. Department of Nephrology Dialysis Transplantation, University of Liège, CHU de Liège, Liège, Belgium

    P. Delanaye

  5. Pôle de Pathologie Rhumatismale, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

    A. Durnez, J.-P. Devogelaer & A. Nzeusseu Toukap

  6. Department of Bone Diseases, Hôpitaux Universitaires Genève, Geneva, Switzerland

    S. L. Ferrari

  7. Gerontology and Geriatrics Section, Department of Clinical and Experimental Medicine, K.U. Leuven, Leuven, Belgium

    E. Gielen

  8. Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium

    S. Goemaere

  9. Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium

    J.-M. Kaufman

  10. Centre Académique de Recherche et d’Expérimentation en Santé SPRL (CARES SPRL), Liège, Belgium

    J.-M. Kaufman & J.-Y. Reginster

  11. Burn Centre and General Intensive Care Department, University of Liège, CHU de Liège, Liège, Belgium

    A.-F. Rousseau

  12. Department of Gynaecology–Obstetrics, Université Libre de Bruxelles, Brussels, Belgium

    S. Rozenberg

  13. Division of Diabetes, Nutrition and Metabolic Disorders, University of Liège CHU de Liège, Liège, Belgium

    A. J. Scheen

  14. Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium

    J.-J. Body

Authors
  1. E. Cavalier
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  2. P. Bergmann
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  3. O. Bruyère
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  4. P. Delanaye
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  5. A. Durnez
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  6. J.-P. Devogelaer
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  7. S. L. Ferrari
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  8. E. Gielen
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  9. S. Goemaere
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  10. J.-M. Kaufman
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  11. A. Nzeusseu Toukap
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  12. J.-Y. Reginster
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  13. A.-F. Rousseau
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  14. S. Rozenberg
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  15. A. J. Scheen
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  16. J.-J. Body
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Corresponding author

Correspondence to E. Cavalier.

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Conflicts of interest

Etienne Cavalier, Pierre Bergmann, Olivier Bruyère, Pierre Delanaye, Anne Durnez, Jean-Pierre Devogelaer, Serge L. Ferrari, Evelien Gielen, Stefan Goemaere, Jean-Marc Kaufman, Adrien Nzeusseu Toukap, Jean-Yves Reginster, Anne-Françoise Rousseau, Serge Rozenberg, André J. Scheen and Jean-Jacques Body declare that they have no conflicts of interests related to this manuscript.

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Cavalier, E., Bergmann, P., Bruyère, O. et al. The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club. Osteoporos Int 27, 2181–2195 (2016). https://doi.org/10.1007/s00198-016-3561-3

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  • DOI: https://doi.org/10.1007/s00198-016-3561-3

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