Abstract
Introduction and hypothesis
Female urethral stricture (FUS) is an uncommon entity. Although there is no clinical consensus on the best modality of treatment, several studies have been published describing different techniques of FUS management. We carried out a literature review of the different surgical techniques used in the management of FUS and their results.
Methods
We performed a systematic search of the PubMed and EMBASE databases and several cross-references. We grouped the data available from the studies into four general treatment categories.
Results
We reported 35 studies (488 patients) with outcome measures; 53.48% of cases were presumably idiopathic in origin. A history of prior intervention was described in 91.29% of cases. As a surgical intervention, urethral dilatation (UD) had the lowest success rate of only 41.25%. In contrast, local flaps performed better (92.54% success rate) than local or oral grafts (87.30% and 89.94%, respectively). Only 9.43% of patients experienced mild to moderate post-surgery de novo incontinence; most of them recovered with pelvic floor exercises.
Conclusion
In practice, UD is tried first for FUS, at least once, before urethroplasty. In case of failure or short recurrence following UD, urethroplasty should not be delayed. In experienced hands, urethroplasty has a better outcome.
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Abbreviations
- FUS:
-
Female urethral stricture
- UD:
-
Urethral dilatation
- BMG:
-
Buccal mucosal graft
- LMG:
-
Lingual mucosal graft
- VG:
-
Vaginal graft
- BOO:
-
Bladder outlet obstruction
- CISC:
-
Clean intermittent self-catheterisation
References
Carr LK, Webster GD. Bladder outlet obstruction in women. Urologic Clin North Am. 1996;23(3):385–91.
Groutz A, Blaivas JG, Chaikin DC. Bladder outlet obstruction in women: definition and characteristics. Neurourol Urodynamics: Off J Int Continence Soc. 2000;19(3):213–20.
Podestá ML, Jordan GH. Pelvic fracture urethral injuries in girls. J Urol. 2001;165(5):1660–5.
Nitti VW, Tu LM, Gitlin J. Diagnosing bladder outlet obstruction in women. J Urol. 1999;161(5):1535–40.
Santucci RA, Payne CK, Saigal CS. Urologic diseases in America project. Office dilation of the female urethra: a quality of care problem in the field of urology. J Urol. 2008;180(5):2068–75.
Osman NI, Mangera A, Chapple CR. A systematic review of surgical techniques used in the treatment of female urethral stricture. Eur Urol. 2013;64(6):965–73.
Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS med. 2009;6(7):e1000097.
Jeremy Howick et al. OCEBM Levels of Evidence Working Group*. “The Oxford Levels of Evidence 2”, 2011.
Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, et al. Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evidence Synthesis. 2020;18(10):2127–33.
Smith AL, Ferlise VJ, Rovner ES. Female urethral strictures: successful management with long-term clean intermittent catheterisation after urethral dilatation. BJU Int. 2006;98(1):96–9.
Blaivas JG, Santos JA, Tsui JF, Deibert CM, Rutman MP, Purohit RS, et al. Management of urethral stricture in women. J Urol. 2012;188(5):1778–82.
Romman AN, Alhalabi F, Zimmern PE. Distal intramural urethral pathology in women. J Urol. 2012;188(4):1218–23.
Popat S, Zimmern PE. Long-term management of luminal urethral stricture in women. Int Urogynecol J. 2016;27(11):1735–41.
Tanello M, Frego E, Simeone C, Cunico SC. Use of pedicle flap from the labia minora for the repair of female urethral strictures. Urol Int. 2002;69(2):95–8.
Montorsi F, Salonia A, Centemero A, Guazzoni G, Nava L, Da Pozzo LF, et al. Vestibular flap urethroplasty for strictures of the female urethra. Urol Int. 2002;69(1):12–6.
Schwender CE, Ng L, McGuire E, Gormley EA. Technique and results of urethroplasty for female stricture disease. J Urol. 2006;175(3):976–80.
Simonato A, Varca V, Esposito M, Carmignani G. Vaginal flap urethroplasty for wide female stricture disease. J Urol. 2010;184(4):1381–5.
Gormley EA. Vaginal flap urethroplasty for female urethral stricture disease. Neurourol Urodyn. 2010;29(S1):S42–5.
Önol FF, Antar B, Köse O, Erdem MR, Önol ŞY. Techniques and results of urethroplasty for female urethral strictures: our experience with 17 patients. Urology. 2011;77(6):1318–24.
Kowalik C, Stoffel JT, Zinman L, Vanni AJ, Buckley JC. Intermediate outcomes after female urethral reconstruction: graft vs flap. Urology. 2014;83(5):1181–5.
Spilotros M, Malde S, Solomon E, Grewal M, Mukhtar BM, Pakzad M, et al. Female urethral stricture: a contemporary series. World J Urol. 2017;35(6):991–5.
Romero-Maroto J, Verdú-Verdú L, Gómez-Pérez L, Pérez-Tomás C, Pacheco-Bru JJ, López-López A. Lateral-based anterior vaginal wall flap in the treatment of female urethral stricture: efficacy and safety. Eur Urol. 2018;73(1):123–8.
Hajebrahimi S, Maroufi H, Mostafaei H, Salehi-Pourmehr H. Reconstruction of the urethra with an anterior vaginal mucosal flap in female urethral stricture. Int Urogynecol J. 2019;30(12):2055–60.
Tsivian A, Sidi AA. Dorsal graft urethroplasty for female urethral stricture. J Urol. 2006;176(2):611–3.
Petrou SP, Rogers AE, Parker AS, Green KM, McRoberts JW. Dorsal vaginal graft urethroplasty for female urethral stricture disease. BJU Int. 2012;110(11c):E1090–5.
Singh M, Kapoor R, Kapoor D, Kapoor R, Srivastav A, Chipde S. Dorsal onlay vaginal graft urethroplasty for female urethral stricture. Indian J Urol: IJU: J Urol Soc India. 2013;29(2):124.
Önol FF, Önol ŞY, Tahra A, Boylu U. Ventral inlay labia minora graft urethroplasty for the management of female urethral strictures. Urology. 2014;83(2):460–4.
Gozzi C, Roosen A, Bastian PJ, Karl A, Stief C, Tritschler S. Volar onlay urethroplasty for reconstruction of female urethra in recurrent stricture disease. BJU Int. 2011;107(12):1964–6.
Rehder P, Glodny B, Pichler R, Exeli L, Kerschbaumer A, Mitterberger MJ. Dorsal urethroplasty with labia minora skin graft for female urethral strictures. BJU Int. 2010;106(8):1211–4.
Manasa T, Khattar N, Tripathi M, Varshney A, Goel H, Sood R. Dorsal onlay graft urethroplasty for female urethral stricture improves sexual function: short-term results of a prospective study using vaginal graft. Indian J Urol: IJU: J Urol Soc India. 2019;35(4):267.
Chakraborty JN, Vyas N. Dorsal vaginal graft urethroplasty in female urethral stricture: a contemporary series. Afr J Urol. 2021;27(1):1–1.
Migliari R, Leone P, Berdondini E, De Angelis M, Barbagli G, Palminteri E. Dorsal buccal mucosa graft urethroplasty for female urethral strictures. J Urol. 2006;176(4):1473–6.
Berglund RK, Vasavada S, Angermeier K, Rackley R. Buccal mucosa graft urethroplasty for recurrent stricture of female urethra. Urology. 2006;67(5):1069–71.
Sharma GK, Pandey A, Bansal H, Swain S, Das SK, Trivedi S, et al. Dorsal onlay lingual mucosal graft urethroplasty for urethral strictures in women. BJU Int. 2010;105(9):1309–12.
Castillo OA, Sepulveda F, Feria-Flores MA. Urethroplasty with dorsal oral mucosa graft in female urethral stenosis. Actas Urológicas Españolas (English Edition). 2011;35(4):246–9.
Goel A, Paul S, Dalela D, Sankhwar P, Sankhwar SN, Singh V. Dorsal onlay buccal mucosal graft urethroplasty in female urethral stricture disease: a single-center experience.
Powell CR, Daniels D. Dorsal onlay buccal urethroplasty in the female is associated with high quality of life using validated lower urinary tract symptom instruments. Urology Pract. 2017;4(1):48–53.
Mukhtar BM, Spilotros M, Malde S, Greenwell TJ. Ventral-onlay buccal mucosa graft substitution urethroplasty for urethral stricture in women. BJU Int. 2017;120(5):710–6.
Nayak P, Mandal S, Das M. Ventral-inlay buccal mucosal graft urethroplasty for female urethral stricture. Indian J Urol: IJU: J Urol Soc India. 2019;35(4):273.
Ozlulerden Y, Celen S, Zumrutbas AE, Aybek Z. Female buccal mucosa graft urethroplasty: a new modified ventral onlay "AZ" technique. Int Urogynecol J. 2020;4.
Hampson LA, Myers JB, Vanni AJ, Virasoro R, Smith TG III, Capiel L, et al. Dorsal buccal graft urethroplasty in female urethral stricture disease: a multi-center experience. Translational androl Urol. 2019;8(Suppl 1):S6.
Gomez RG, Segura FJ, Saavedra A, Campos RA. Female urethral reconstruction: dorsal buccal mucosa graft onlay. World J Urol. 2019;21:1–8.
Coguplugil AE, Ebiloglu T, Sarikaya S, Yilmaz S, Topuz B, Gurdal M. Ventral onlay buccal mucosa graft urethroplasty for female urethral stricture. Int J Urol. 2021
Flisser AJ, Blaivas JG. Outcome of urethral reconstructive surgery in a series of 74 women. J Urol. 2003;169(6):2246–9.
Brannan D. Stricture of the female urethra. J Urol. 1951;66(2):242–53.
Hoag N, Chee J. Surgical management of female urethral strictures. Translational androl Urol. 2017;6(Suppl 2):S76.
West C, Lawrence A. Female urethroplasty: contemporary thinking. World J Urol. 2019;37(4):619–29.
Defreitas GA, Zimmern PE, Lemack GE, Shariat SF. Refining diagnosis of anatomic female bladder outlet obstruction: comparison of pressure-flow study parameters in clinically obstructed women with those of normal controls. Urology. 2004;64(4):675–9.
Chassagne S, Bernier PA, Haab F, Roehrborn CG, Reisch JS, Zimmern PE. Proposed cutoff values to define bladder outlet obstruction in women. Urology. 1998;51(3):408–11.
Kuo HC. Videourodynamic characteristics and lower urinary tract symptoms of female bladder outlet obstruction. Urology. 2005;66(5):1005–9.
Tincello DG, Owen RK, Slack MC, Abrams KR. Validation of the patient global impression scales for use in detrusor overactivity: secondary analysis of the RELAX study. BJOG Int J Obstet Gynaecol. 2013;120(2):212–6.
Ackerman AL, Blaivas J, Anger JT. Female urethral reconstruction. Current bladder dysfunction reports. 2010;5(4):225–32.
Agochukwu-Mmonu N, Srirangapatanam S, Cohen A, Breyer B. Female urethral strictures: review of diagnosis, etiology, and management. Current Urol Reports. 2019;20(11):1–6.
El-Kasaby AW, Fath-Alla M, Noweir AM, El-Halaby MR, Zakaria W, El-Beialy MH. The use of buccal mucosa patch graft in the management of anterior urethral strictures. J Urol. 1993;149(2):276–8.
Barbagli G, Selli C, Tosto A, Palminteri E. Dorsal free graft urethroplasty. J Urol. 1996;155(1):123–6.
Faiena I, Koprowski C, Tunuguntla H. Female urethral reconstruction. J Urol. 2016;195(3):557–67.
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JNC: Data collection, manuscript writing and made a substantial contribution to the concept and design of the work with drafting, acquisition, analysis and interpretation of data.
AC: Analysis and interpretation of data, manuscript editing.
NV: Data collection, revision of the manuscript, critical analysis of the manuscript content.
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Chakraborty, J.N., Chawla, A. & Vyas, N. Surgical interventions in female urethral strictures: a comprehensive literature review. Int Urogynecol J 33, 459–485 (2022). https://doi.org/10.1007/s00192-021-04906-8
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DOI: https://doi.org/10.1007/s00192-021-04906-8