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Mesenchymal stromal cells as a salvage treatment for confirmed acute respiratory distress syndrome: preliminary data from a single-arm study

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We declared that materials described in the manuscript, including all relevant raw data, will be freely available to any scientist wishing to use them for noncommercial purposes, without breaching participant confidentiality.

References

  1. Schenck EJ, Oromendia C, Torres LK, Berlin DA, Choi AMK, Siempos II (2019) Rapidly improving ARDS in therapeutic randomized controlled trials. Chest 155(3):474–482. https://doi.org/10.1016/j.chest.2018.09.031

    Article  PubMed  Google Scholar 

  2. Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG, LS Investigators, ETG (2018) Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med 44(5):564–577. https://doi.org/10.1007/s00134-018-5152-6

    Article  PubMed  Google Scholar 

  3. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD (2019) Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med 7(2):154–162. https://doi.org/10.1016/S2213-2600(18)30418-1

    Article  PubMed  Google Scholar 

  4. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee J-W, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA (2015) Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med 3(1):24–32. https://doi.org/10.1016/s2213-2600(14)70291-7

    Article  PubMed  Google Scholar 

  5. Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, Xu J (2014) Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study. Respir Res 15:39. https://doi.org/10.1186/1465-9921-15-39

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yip HK, Fang WF, Li YC, Lee FY, Lee CH, Pei SN, Ma MC, Chen KH, Sung PH, Lee MS (2020) Human umbilical cord-derived mesenchymal stem cells for acute respiratory distress syndrome. Crit Care Med 48(5):e391–e399. https://doi.org/10.1097/CCM.0000000000004285

    Article  CAS  PubMed  Google Scholar 

  7. Parhar KKS, Zjadewicz K, Soo A, Sutton A, Zjadewicz M, Doig L, Lam C, Ferland A, Niven DJ, Fiest K, Stelfox HT, Doig CJ (2019) Epidemiology, mechanical power, and 3-year outcomes in ARDS patients using standardized screening: an observational cohort study. Ann Am Thorac Soc 16(10):1263–1272. https://doi.org/10.1513/AnnalsATS.201812-910OC

    Article  PubMed  PubMed Central  Google Scholar 

  8. Villar J, Blanco J, del Campo R, Andaluz-Ojeda D, Diaz-Dominguez FJ, Muriel A, Corcoles V, Suarez-Sipmann F, Tarancon C, Gonzalez-Higueras E, Lopez J, Blanch L, Perez-Mendez L, Fernandez RL, Kacmarek RM, Spanish Initiative for Epidemiology S, Therapies for AN (2015) Assessment of PaO(2)/FiO(2) for stratification of patients with moderate and severe acute respiratory distress syndrome. BMJ Open 5(3):e006812. https://doi.org/10.1136/bmjopen-2014-006812

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We would like to thank all of the physicians, nurses, technicians and patients involved at each participating ICUs for their dedication to the study. We also thank Xiaohui Huang, Liang Peng from Clinical Medicine Research Center for their kind help with project executiveness.

Study Group investigators

Haijin Lv, Huimin Yi, Xiaomeng, Yi, Yuling An, Xuxia Wei, Pinglan Lu, Mingming Fan, Xunan Gong, Jianrong Liu, Jun Guo and Mi Zhou (Critical Care Medicine, Surgical and Transplant Intensive Care Unit), Jianrong Liu (Transplant Intensive Care Unit); Yang Yang, Fei Han and Guihua Chen (Transplant center); Yanhong Wang, Yunfeng Shi and Benquan Wu (Pulmonary and Critical care, Medical Intensive Care Unit); Ying Xian, Xiaogang Bi and Kouxing Zhang (Critical Care medicine and General Intensive Care Unit); Qi Zhang, Wenjie Chen, Jianxi Lu and Chang Liu (Biotherapy Center); Yuefei Guo (Diagnostic Radiology). All of the above investigators are from two branches of the third affiliated hospital of Sun Yat-sen University.

Funding

This study was funded by The Third Affiliated Hospital of Sun Yat-sen University, Clinical Research Program QHJH201804. The supply and quality control of UCMSCs were funded by National Science and Technology Major Project of China, 2018ZX10723203, 2018ZX10723203; National Key Research and Development Program of China, 2017YFA0104304; National Natural Science Foundation of China, 81770651; Science and Technology Planning Project of Guangdong Province of China, 2019B020236003; Guangdong Natural Science Foundation, 2018A0303130305.

Author information

Author notes

  1. Haijin Lv and Wenjie Chen have contributed equally to this work.

Authors and Affiliations

  1. Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China

    Wenjie Chen & Qi Zhang

  2. Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China

    Andy Peng Xiang

  3. Transplant Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China

    Yang Yang

  4. Surgical and Transplant Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China

    Haijin Lv & Huimin Yi

Authors
  1. Haijin Lv
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  2. Wenjie Chen
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  3. Andy Peng Xiang
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  4. Qi Zhang
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  5. Yang Yang
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  6. Huimin Yi
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Consortia

on behalf of the Study Group investigators

  • Haijin Lv
  • , Huimin Yi
  • , Xiaomeng Yi
  • , Yuling An
  • , Xuxia Wei
  • , Pinglan Lu
  • , Mingming Fan
  • , Xunan Gong
  • , Jianrong Liu
  • , Jun Guo
  • , Mi Zhou
  • , Jianrong Liu
  • , Yang Yang
  • , Fei Han
  • , Guihua Chen
  • , Yanhong Wang
  • , Yunfeng Shi
  • , Benquan Wu
  • , Ying Xian
  • , Xiaogang Bi
  • , Kouxing Zhang
  • , Qi Zhang
  • , Wenjie Chen
  • , Jianxi Lu
  • , Chang Liu
  •  & Yuefei Guo

Contributions

HL, HY and WC designed the project and contributed equally to this work. Andy XP, QZ and YY supervised the project. QZ and WC provided UCMSCs. HL, HY, and the study group investigators performed the research and collected data; HL analyzed and wrote the manuscript. All the authors contributed to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; and drafted the work or revising it critically for important intellectual content; and finally approved the version to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Huimin Yi.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethics approval

The study was approved in 2017 [Approval No. 2017-22] and revised in 2019 [Approval No. 2019-19] by the Stem Cells Specific Ethics Committee of the Third affiliated hospital of Sun Yat-sen University and registered with ClinicalTrials.gov, number NCT03608592.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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The Study Group investigators names are listed in Acknowledgement section

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Supplementary material 2 (DOCX 126 kb)

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Lv, H., Chen, W., Xiang, A.P. et al. Mesenchymal stromal cells as a salvage treatment for confirmed acute respiratory distress syndrome: preliminary data from a single-arm study. Intensive Care Med 46, 1944–1947 (2020). https://doi.org/10.1007/s00134-020-06122-2

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  • DOI: https://doi.org/10.1007/s00134-020-06122-2

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