Skip to main content
Log in

Dexmedetomidin als First-Line-Sedativum – Ende vom Lied?

First-line sedation with dexmedetomidine—end of the story?

  • Journal Club
  • Published:
Medizinische Klinik - Intensivmedizin und Notfallmedizin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Mizobe T, Maghsoudi K, Sitwala K, Tianzhi G, Ou J, Maze M (1996) Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. J Clin Invest 98(5):1076–1080

    Article  CAS  Google Scholar 

  2. Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J (2012) Dexmedetomidine for long-term sedation I: dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. J Am Med Assoc 307(11):1151–1160

    Article  CAS  Google Scholar 

  3. Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F et al (2016) Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial. J Am Med Assoc 315(14):1460–1468

    Article  CAS  Google Scholar 

  4. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA et al (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. J Am Med Assoc 298(22):2644–2653

    Article  CAS  Google Scholar 

  5. Shehabi Y, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, Bin Kadiman S, McArthur CJ, Murray L, Reade MC et al (2019) Early sedation with dexmedetomidine in critically ill patients. N Engl J Med 380(26):2506–2517

    Article  Google Scholar 

  6. Coursin DB, Skrobik Y (2019) What is safe sedation in the ICU? N Engl J Med 380(26):2577–2578

    Article  Google Scholar 

  7. Strom T, Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375:475–480

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Björn Weiss.

Ethics declarations

Interessenkonflikt

B. Weiss erklärt, in der Vergangenheit persönliche Honorare von den Firmen Orion Pharma und Dr. F. Köhler Chemie erhalten zu haben.

Additional information

Redaktion

S. Kluge, Hamburg

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weiss, B. Dexmedetomidin als First-Line-Sedativum – Ende vom Lied?. Med Klin Intensivmed Notfmed 115, 260–262 (2020). https://doi.org/10.1007/s00063-019-00627-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00063-019-00627-5

Navigation