Abstract
Background
The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) has not been defined. The aim of this study was to examine the circulating SDF-1 levels in hospitalized heart failure (HHF) patients.
Methods
Circulating SDF-1 and other clinical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and echocardiographic parameters, were measured in HHF patients (n = 69) and healthy control subjects (n = 35).
Results
The circulating SDF-1 level was significantly greater in patients with HF (5,101 ± 1,977 pg/ml) compared with the control subjects (1,879 ± 1,417 pg/ml; p < 0.001). Circulating SDF-1 levels were positively correlated with NT-proBNP (r = 0.46 p < 0.001) and CRP (r = 0.53 p < 0.001) levels, and negatively correlated with left ventricular ejection fraction values (r = − 0.41, p < 0.001).
Conclusion
The level of circulating SDF-1 increases in HHF patients.
Zusammenfassung
Hintergrund
Bisher ist die Rolle der zirkulierenden SDF-1 („stromal cell-derived factor-1“) bei Herzinsuffizienz nicht geklärt. Ziel der vorliegenden Studie war es, die Werte des zirkulierenden SDF-1 bei stationär behandelten Patienten mit Herzinsuffizienz zu untersuchen.
Methoden
Zirkulierender SDF-1 und andere klinische Variablen, einschließlich des NT-proBNP („n-terminal pro-brain natriuretic peptide“), C-reaktiven Proteins (CRP) und echokardiographischer Parameter, wurden bei stationär behandelten Patienten mit Herzinsuffizienz (n = 69) und gesunden Kontrollen gemessen (n = 35).
Ergebnisse
Der Wert des zirkulierenden SDF-1 war bei Patienten mit Herzinsuffizienz signifikant höher (5101 ± 1977 pg/ml) als bei den Kontrollen (1879 ± 1417 pg/ml; p < 0,001). Es bestand eine positive Korrelation der Werte des zirkulierenden SDF-1 mit den Werten für NT-proBNP (r = 0,46; p < 0,001) und CRP (r = 0,53; p < 0,001) und eine negative Korrelation mit den Werten der linksventrikulären Ejektionsfraktion (r = − 0,41; p < 0,001).
Schlussfolgerung
Bei stationär behandelten Patienten mit Herzinsuffizienz kommt es zu einem Anstieg des zirkulierenden SDF-1.
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Compliance with ethical guidelines
Conflict of interest. K. Liu, S. Yang, M. Hou, T. Chen, J. Liu, and B. Yu state that there are no conflicts of interest. All studies on humans described in the present manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current, revised form). Informed consent was obtained from all patients included in studies.
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Liu, K., Yang, ., Hou, M. et al. Increase of circulating stromal cell-derived factor-1 in heart failure patients. Herz 40 (Suppl 1), 70–75 (2015). https://doi.org/10.1007/s00059-014-4169-z
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DOI: https://doi.org/10.1007/s00059-014-4169-z