Abstract
A simple synthetic route was developed to prepare novel fluoroquinolone derivatives from amino acid salts. A facile route preparing the quinolone intermediates in one pot was explored which can facilitate the industrial operation. A series of new compounds were prepared conveniently and characterized by IR, 1H NMR, MS, and elemental analysis. The preliminary bioassays results revealed that they have certain antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, and Aspergillus fumigatus.
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Acknowledgments
The authors are grateful to Zhejiang Provincial Natural Science Foundation of China (No. Y4090052) and National Science and Technology Ministry of China (No. 2007BAI34B05) for providing financial support.
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Zheng, H., Liu, J. & Zhang, P. The simple synthesis and antimicrobial activity of novel fluoroquinolone derivatives from natural amino acid salts. Med Chem Res 21, 53–59 (2012). https://doi.org/10.1007/s00044-010-9509-9
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DOI: https://doi.org/10.1007/s00044-010-9509-9