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Mechanisms of larynx and vocal fold development and pathogenesis

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Abstract

The larynx and vocal folds sit at the crossroad between digestive and respiratory tracts and fulfill multiple functions related to breathing, protection and phonation. They develop at the head and trunk interface through a sequence of morphogenetic events that require precise temporo-spatial coordination. We are beginning to understand some of the molecular and cellular mechanisms that underlie critical processes such as specification of the laryngeal field, epithelial lamina formation and recanalization as well as the development and differentiation of mesenchymal cell populations. Nevertheless, many gaps remain in our knowledge, the filling of which is essential for understanding congenital laryngeal disorders and the evaluation and treatment approaches in human patients. This review highlights recent advances in our understanding of the laryngeal embryogenesis. Proposed genes and signaling pathways that are critical for the laryngeal development have a potential to be harnessed in the field of regenerative medicine.

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Acknowledgements

This work was supported by grants NIH NIDCD R01 DC004336 and R01 DC012773.

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  1. Department of Surgery, University of Wisconsin Madison, 5103 WIMR, 1111 Highland Ave, Madison, WI, 53705, USA

    Vlasta Lungova & Susan L. Thibeault

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Lungova, V., Thibeault, S.L. Mechanisms of larynx and vocal fold development and pathogenesis. Cell. Mol. Life Sci. 77, 3781–3795 (2020). https://doi.org/10.1007/s00018-020-03506-x

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