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Roles of vitamins in stem cells

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Abstract

Stem cells can differentiate to diverse cell types in our body, and they hold great promises in both basic research and clinical therapies. For specific stem cell types, distinctive nutritional and signaling components are required to maintain the proliferation capacity and differentiation potential in cell culture. Various vitamins play essential roles in stem cell culture to modulate cell survival, proliferation and differentiation. Besides their common nutritional functions, specific vitamins are recently shown to modulate signal transduction and epigenetics. In this article, we will first review classical vitamin functions in both somatic and stem cell cultures. We will then focus on how stem cells could be modulated by vitamins beyond their nutritional roles. We believe that a better understanding of vitamin functions will significantly benefit stem cell research, and help realize their potentials in regenerative medicine.

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Acknowledgements

This work was supported by the Science and Technology Development Fund of Macau SAR (FDCT/131/2014/A3, FDCT/056/2015/A2 and FDCT/0059/2019/A1) and University of Macau Multiyear Research Grant (MYRG2018-00135-FHS).

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  1. Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

    Carlos Godoy-Parejo, Chunhao Deng, Yumeng Zhang, Weiwei Liu & Guokai Chen

  2. Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

    Weiwei Liu & Guokai Chen

  3. Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

    Guokai Chen

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Godoy-Parejo, C., Deng, C., Zhang, Y. et al. Roles of vitamins in stem cells. Cell. Mol. Life Sci. 77, 1771–1791 (2020). https://doi.org/10.1007/s00018-019-03352-6

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