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Free fatty acid G-protein coupled receptor signaling in M1 skewed white adipose tissue macrophages

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Abstract

Obesity is associated with the establishment and maintenance of a low grade, chronically inflamed state in the white adipose tissue (WAT) of the body. The WAT macrophage population is a major cellular participant in this inflammatory process that significantly contributes to the pathophysiology of the disease, with the adipose depots of obese individuals, relative to lean counterparts, having an elevated number of macrophages that are skewed towards a pro-inflammatory phenotype. Alterations in the WAT lipid micro-environment, and specifically the availability of free fatty acids, are believed to contribute towards the obesity-related quantitative and functional changes observed in these cells. This review specifically addresses the involvement of the five G-protein coupled free fatty acid receptors which bind exogenous FFAs and signal in macrophages. Particular focus is placed on the involvement of these receptors in macrophage migration and cytokine production, two important aspects that modulate inflammation.

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Acknowledgments

Warren Antonio Vieira was funded by the Faculty of Medicine and Health Sciences, Stellenbosch University. Hanél Sadie-Van Gijsen and William Ferris are funded by the South African Medical Research Council and the South African National Research Foundation.

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  1. Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa

    Warren Antonio Vieira, Hanél Sadie-Van Gijsen & William Frank Ferris

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  1. Warren Antonio Vieira
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Vieira, W.A., Sadie-Van Gijsen, H. & Ferris, W.F. Free fatty acid G-protein coupled receptor signaling in M1 skewed white adipose tissue macrophages. Cell. Mol. Life Sci. 73, 3665–3676 (2016). https://doi.org/10.1007/s00018-016-2263-5

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  • DOI: https://doi.org/10.1007/s00018-016-2263-5

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