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Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction

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Abstract

Introduction

Sepsis-induced myocardial dysfunction (SIMD) is a condition manifested by an intrinsic myocardial systolic and diastolic dysfunction during sepsis, which is associated with worse clinical outcomes and a higher mortality.

Materials and methods

Several pathophysiological mechanisms including mitochondrial dysfunction, abnormal body immune reaction, metabolic reprogramming, excessive production of reactive oxygen species (ROS), and disorder of calcium regulation have been involved in SIMD. Mitophagy has potential role in protecting myocardial cells in sepsis, especially in survivors.

Conclusion

In the current review, we focus on the role of mitochondrial dysfunction and other mitochondria-related mechanisms including immunologic imbalance, energetic reprogramming, mitophagy, and pyroptosis in the mechanisms of SIMD.

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Funding

This study was funded by National Natural Science Foundation of China (Nos. 81772110, 82072202).

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Authors and Affiliations

  1. Department of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wu Hou District, Chengdu, 610041, China

    Hang Yang

  2. Department of Critical Care Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road No. 88, Hangzhou, 310000, Zhejiang province, China

    Zhaocai Zhang

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  1. Hang Yang
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Hang Yang contributed to design and draft the manuscript. And Zhaocai Zhang contributed to design and review the manuscript.

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Correspondence to Zhaocai Zhang.

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Yang, H., Zhang, Z. Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction. Inflamm. Res. 70, 379–387 (2021). https://doi.org/10.1007/s00011-021-01447-0

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