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Biological tests of physiologically active compounds (approaches): Communication II

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Abstract

This review considers the methods of investigation proposed by L. A. Piruzyan in the field of preclinical trials of physiologically active compounds: (1) the search for new physiologically active compounds illustrated by analysis of the developmental mechanisms of some diseases, such as jaundice of the newborn, renal and liver insufficiency, acute drug-induced intoxication, discoid and systemic lupus erythematosus, and lupus-like syndrome; (2) experimental studies on safety of medicinal substances—the testing of substances for mutagenicity and embryotoxicity, the preparation of compounds with antimutagenic and anticarcinogenic properties, the determination of preserved blood characteristics; (3) the stabilization of medicinal preparations for use—with drug oxidation inhibitors, and substances contained in liposomes. The ligand pathology concept is presented. The necessity of an individualized approach for assessment of chemical compound safety for humans in emphasized: it should be based on the activity determination of certain enzymes in each subject.

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References

  1. Landau, M.A., Biological Tests of Physiologically Active Compounds (Methodology). Communication I,Fiziol. Chel., 1999, vol. 25, no. 5, p. 115.

    CAS  Google Scholar 

  2. Landau, M.A.,Molekulyarnye mekhanizmy deistviya fiziologicheskikh aktivnykh soedinenii (Molecular Action Mechanisms of Physiologically Active Compounds), Moscow, Nauka, 1981.

    Google Scholar 

  3. Landau, M.A.,Molekulyarnaya priroda otdel’nykh fiziologicheskikh protsessov (Molecular Nature of Individual Physiological Processes), Moscow: Nauka, 1985.

    Google Scholar 

  4. Petkov, V.,Lekarstvo, organism, farmakologicheskii effekt (Drug, Organism, Pharmacological Effect), Sofia: Meditsina i Fizkul’tura, 1974.

    Google Scholar 

  5. Petkov, V.,Osnovnye mekhanizmy nezhelatel’nykh effektov lekarstv. Lekarstvennaya bolezn’ (Basic Mechanisms of Drug Undesirable Effects. Drug Disease), Sofia: Meditsina i Fizkul’tura, 1976, p. 14.

    Google Scholar 

  6. Cheger, S.I.,Transportnaya funktsiya syvorotochnogo al’bumina (Transport Function of Serum Albumin), Bucharest: Akad. SRR, 1975.

    Google Scholar 

  7. Piruzyan, L.A. and Landau, M.A.,Voprosy meditsinskoi biofiziki (Problems of Medical Biophysics), Moscow: Nauka, 1988.

    Google Scholar 

  8. Landau, M.A., Markovich, M.E., and Rudzit, E.A., Studies on Thermodynamics of Small Molecule Complexing with Proteins,Zh. Fiz. Khim., 1977, vol. 51, no. 6, p. 1495.

    CAS  Google Scholar 

  9. Markovich, M.N., Landau, M.A., and Rudzit, E.A., About the Interaction of Penicillins with Serum Albumin,Khim.-Farm. Zh., 1976, vol. 10, no. 8, p. 16.

    CAS  Google Scholar 

  10. Markovich, M.N., Landau, M.A., and Rudzit, E.A., About the Molecular Mechanism of Penicillin Binding with Serum Albumin,Antibiotiki, 1977, vol. 22, no. 10, p. 901.

    PubMed  CAS  Google Scholar 

  11. Markovich, M.N., Rudzit, E.A., and Landau, M.A., Molecular Aspects of Penicillin Interaction with Serum Albumin,Antibiotiki, 1978, vol. 23, no. 7, p. 654.

    PubMed  CAS  Google Scholar 

  12. Landau, M.A., Markovich, M.N., and Piruzyan, L.A., Studies on the Thermodynamics and Nature of Interaction between Serum Albumin and Penicillins,Biochim. Biophys. Acta, 1977, vol. 493, no. 1, p. 1.

    PubMed  CAS  Google Scholar 

  13. Landau, M.A., NMR Studies on the Complexing between Drug Molecules and Biopolymers and Biomembranes,Khim.-Farm. Zh., 1976, vol. 10, no. 11, p. 29.

    CAS  Google Scholar 

  14. Kharakhonycheva, N.V. and Lavretskaya, E.F., Studies on the Interaction of Psychotropic and Anticonvulsant Drugs with Serum Albumin Using the Spin Label Method,Khim.-Farm. Zh., 1976, vol. 10, no. 9, p. 7.

    CAS  Google Scholar 

  15. Kharakhonycheva, N.V., Rudzit, E.A., Raikhman, L.M., and Moshkovskii, Yu.Sh., Studies on the Interaction of Human Serum Albumin with Penicillins Using the Spin Label Method,Antibiotiki, 1975, vol. 20, no. 10, p. 917.

    PubMed  CAS  Google Scholar 

  16. Bondareva, A.P., Kolosov, M.V., and Landau, M.A., The Complexing of Co(II), Fe(II), and Mn(II) with Plasma Proteins,Koordinats. Khim., 1980, vol. 6, no. 2, p. 264.

    CAS  Google Scholar 

  17. Bondareva, A.P. and Landau, M.A., The Complexing of Cobalt (II) Cation with Fibrinogen,Zh. Fiz. Khim., 1981, vol. 55, no. 3, p. 683.

    CAS  Google Scholar 

  18. Erukhimovich, I.Ya., Bondareva, A.P., and Landau, M.A., Theoretical Analysis of Cooperative Binding of Transition Metal Cations with Serum Albumin and γ-Globulin,Zh. Fiz. Khim., 1981, vol. 55, no. 5, p. 870.

    CAS  Google Scholar 

  19. Brukhimovich, I.A. and Landau, M.A., Theoretical Analysis of Cooperative Binding between Small Molecules and Macromolecules, 2. Calorimetric Curves,Zh. Fiz. Khim., 1985, vol. 59, no. 2, p. 457.

    Google Scholar 

  20. Landau, M.A. and Bondareva, A.P., About the Binding Cooperativity of Co2+ and Mn2+ Ions with Serum Albumin and γ-Globulin,Zh. Fiz. Khim., 1980, vol. 54, no. 1, p. 193.

    CAS  Google Scholar 

  21. Kharakhonycheva, N.V., Bondareva, A.P., and Landau, M.A., EPR Studies on the Interaction of Serum Albumin with Manganese (II) Cation,Zh. Fiz. Khim., 1981, vol. 55, no. 3, p. 618.

    CAS  Google Scholar 

  22. Landau, M.A., Molecular Regulators of Protein Conformation,Khim.-Farm. Zh., 1982, vol. 16, no. 5, p. 521.

    CAS  Google Scholar 

  23. Landau, M.A., About Geometry of Nuclear Acid Sugar Residues,Izv. Akad. Nauk SSSR. Ser. Biol., 1990, no. 5, p. 649.

    Google Scholar 

  24. Kovalev, I.E. and Polevaya, O.Yu.,Antitela k fiziologicheski aktivnym soedineniyam (Antibodies to Physiologically Active Compounds), Moscow: Meditsina, 1981.

    Google Scholar 

  25. Kovalev, I.E. and Polevaya, O.Yu.,Biokhimicheskie osnovy immuniteta k nizkomolekulyarnym khimicheskim soedineniyam (Biochemical Basis of Immunity to Low-Molecular-weight Compounds), Moscow: Nauka, 1985.

    Google Scholar 

  26. Podymov, V.K., Biomedical Principles of the General Concept of Lupus Erythematosus Pathogenesis,Vopr. Revm., 1979, no. 1, p. 45.

    PubMed  Google Scholar 

  27. Podymov, V.K.,Krasnaya volchanka (Lupus Erythematosus), Yerevan: Aiastan, 1981.

    Google Scholar 

  28. Myshkin, A.E. and Sakharov, V.N., Photochemistry of Bilirubin,Usp. Khim., 1982, vol. 51, no. 1, p. 72.

    CAS  Google Scholar 

  29. Girotti, A., Mechanisms of Photosensibilization,Photochem. Photobiol., 1983, vol. 38, p. 745.

    Article  PubMed  CAS  Google Scholar 

  30. Jori, G. and Spikes, J.B., Photochemistry of Porphyrin, inTopics in Photomedicine, New York: Plenum Press, 1984, p. 183.

    Google Scholar 

  31. Pottier, R. and Truscott, T.G., The Photochemistry of Haematoporphyrin and Related Systems,Int. J. Radiat. Biol., 1986, vol. 50, no. 3, p. 421.

    Article  CAS  Google Scholar 

  32. Piruzyan, L.A., Dement’ev, V.A., Landau, M.A., and Akimov, V.S., About the Nonspecific Photophysiological Immunization,Izv. Akad. Nauk SSSR. Ser. Biol., 1991, no. 4, p. 630.

    Google Scholar 

  33. Bochkov, N.P., Zakharov, A.F., and Ivanov, V.I.,Meditsinskaya genetika (Medical Genetics), Moscow: Meditsina, 1984.

    Google Scholar 

  34. Lents, V.,Meditsinskaya genetika (Medical Genetics), Moscow: Meditsina, 1984.

    Google Scholar 

  35. Piruzyan, L.A., Kharchenko, S.V., Gladkikh, S.P.,et al., Biological Aspects of Periodontosis Pathogenesis,Izv. Akad. Nauk SSSR. Ser. Biol., 1983, no. 2, p. 251.

    Google Scholar 

  36. Podymov V.K., Gladkikh, S.P., and Piruzyan, L.A., Molecular Basis of Ligand Pathology and Chelate Pharmacology,Khim.-Farm. Zh., 1982, vol. 16, no. 1, p. 9.

    CAS  Google Scholar 

  37. Magalashvili, R.D., N-Acetyltransferase and Experimental Production of Peritoneal Cavity Adhesions,Khirurgiya, 1985, no. 4, p. 64.

    Google Scholar 

  38. Fonshtein, L.M., Revazova, Yu. A., Zolotareva, G. N.,et al., Studies on the Mutagenic Activity of Dioxidine,Genetika, 1978, vol. 14, no. 5, p. 900.

    PubMed  CAS  Google Scholar 

  39. Barenboim, G.M. and Malenkov, A.G.,Biologicheski aktivnye veshchestva. Novye printsipy poiska (Biologically Active Compounds. New Principles for Searching), Moscow: Nauka, 1986.

    Google Scholar 

  40. Gol’denberg, V.I., Piruzyan, L. A., Pudel’, M.E.,et al., Homolytic Reactions of Drugs and Stability of Medicinal Forms. II. The Inhibitory Ability of Pyrazolone Derivatives and Their Use for Stabilization of Medicinal Forms,Khim.-Farm. Zh., 1977, vol. 10, no. 11, p. 79.

    Google Scholar 

  41. Tentsova, L.I., Gol’denberg, V.I., Pil’ko, V.A., and Pudel’, M.E., Homolytic Reactions of Drugs and Stability of Medicinal Forms. I. The Interaction of Drugs with Hydroxides and Stability of Lipid-based Pharmaceuticals.Khim.-Farm. Zh. 1978, vol. 12, no. 1, p. 128.

    CAS  Google Scholar 

  42. Gavrilenko, G.A., Kovaleva, N.S., Vakhrusheva, L.L.,et al., The Effect of Oral Administration of Insulin in Liposomes on Certain Metabolic Parameters in Experimental Mechanical Jaundice and Alloxan Diabetes Mellitus,Khim.-Farm. Zh., 1985, vol. 19, no. 2, p. 144.

    CAS  Google Scholar 

  43. Grebenshchikov, Yu.B. and Moshkovskii, Yu.Sh.,Fizikokhimicheskie svoistva, struktura i funktsii insulina (Physicochemical Properties, Structure, and Functions of Insulin),Itogi Nauki, Moscow: VINITI, 1986.

    Google Scholar 

  44. Rossel’s, A.N., Moshkovskii, Yu.Sh., Piruzyan, L.A.,et al., A Possibility to Use Liposomes for Oral Administration of Insulin in Diabetes Mellitus,Khim.-Farm. Zh., 1983, vol. 17, no. 1, p. 52.

    Google Scholar 

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  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 117977, Moscow, Russia

    M. A. Landau

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  1. M. A. Landau
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Deceased.

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Landau, M.A. Biological tests of physiologically active compounds (approaches): Communication II. Hum Physiol 26, 361–365 (2000). https://doi.org/10.1007/BF02760200

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