Abstract
5-Fluorouracil-induced gastro-intestinal toxicity predominantly affects the upper and the lower gastro-intestinal tract. Although 5-fluorouracil (5-FU) can cause severe small-bowel toxicity, this has been reported only in 6 patients with colon carcinoma receiving 5-FU-based therapy. The presentation was extensive ulceration and inflammation of the small bowel with no involvement of the colon. We report another case of this toxicity, and discuss the diagnosis and mechanisms by which 5-FU can induce small-bowel toxicity.
Similar content being viewed by others
Bibliografía
Moertel C, Fleming T, Macdonald J, Haller D, Laurie J, Tangen C. Fluorouracil plus levamisol as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med. 1995;122:321–6.
O'Connell M, Maillard JA, Khan MJ, et al. Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol. 1997;15:246–50.
Meta-Analysis Group in Cancer: Toxicity of 5-fluorouracil in patients with advanced colorectal cancer. Effect of administration schedule and prognostic factors. J Clin Oncol. 1998;16:3537–41.
Toxicity of fluorouracil in patients with advanced colorrectal cancer: effect of administration schedule and prognostic factors. The Meta-analysis Group in Cancer. J Clin Oncol. 1998; p. 3537–41.
Lockich J. 5-Fluorouracil-induced small bowell toxicity in patients with colorectal carcinoma. Cancer. 2000; 88(10):245–6.
Benson AB, Scharg D, Sommerfield HR, et al. American Society of Clinical Oncology. Recommendations on Adjuvant Chemotherapy for stage II Colon Cancer. J Clin Oncol. 2004;22(16):3408–19.
Fata F, Ron IG, Kemeny N, O'Reilly E, Klimstra D y Kelsen DP. 5-Fluorouracil-induced small bowel toxicity in patients with colorectal carcinoma. Cancer. 1999;86: 1129–34.
Robben N, Pippas A, Moore J. The syndrome of 5-fluorouracil cardiotoxicity. Cancer. 1993;71:493–509.
Cwikiel M, Albertsson M. 5-fluorouracil-Induced Small Bowel Toxicity in Patients with Colorectal Carcinoma. Cancer. 2000;89(3):711–2.
Zalcberg J, Kerr D, Seymour L, Palmer M. Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Eur J Cancer. 1998;34(12):1871–5.
Kennedy BJ. 5-Fluorouracil Toxicity. Old or New?. Cancer. 1999;86(7):1099–100.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ferrándiz, C.L., Galiana, G.E., Cervera Grau, J.M. et al. Toxicidad en el intestino delgado inducida por 5-fluorouracilo en un paciente con carcinoma colorrectal. Clin Transl Oncol 7, 356–357 (2005). https://doi.org/10.1007/BF02716552
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02716552