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[11C]-labeling of some caffeine derivatives for mapping adenosine A2a receptors by PET technique

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Abstract

[11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives using [11C]-methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35–93%), and can be utilised easily in online preparations. These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A2a receptors.

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Authors and Affiliations

  1. PET Centre, University Medical School of Debrecen, Nagyerdei krt 98, H-4012, Debrecen, Hungary

    I. Boros, G. Horváth, S. Lehel, T. Márián & L. Trón

  2. Department of Pharmacology, University Medical School of Debrecen, Nagyerdei krt 98, H-4012, Debrecen, Hungary

    Z. Kovács

  3. Institute of Nuclear Research of the Hungarian Academy of Science, Bem tér 18/C, H-4026, Debrecen, Hungary

    J. Szentmiklósi

  4. Institute of Isotopes Co. Ltd., P.O. Box 851, H-1525, Budapest, Hungary

    G. Tóth

Authors
  1. I. Boros
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  2. G. Horváth
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  3. S. Lehel
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  4. T. Márián
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  5. Z. Kovács
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  6. J. Szentmiklósi
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  7. G. Tóth
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  8. L. Trón
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Boros, I., Horváth, G., Lehel, S. et al. [11C]-labeling of some caffeine derivatives for mapping adenosine A2a receptors by PET technique. J Radioanal Nucl Chem 242, 309–312 (1999). https://doi.org/10.1007/BF02345557

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  • DOI: https://doi.org/10.1007/BF02345557

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