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EEG development in early treated PKU patients from birth to 6 years of age

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Abstract

In 126 early treated PKU patients (type I and type II) a close EEG follow up was performed from birth up to 6 years of age. A total of 1465 EEGs were performed before and after onset of dietary treatment and on 11 more subsequent occasions. The composition of the background activity was normal up to 6 years when only a small number of the children (19) showed no dominant alpha activity. The frequency of epileptiform activity of generalised as well as focal type was low in the first 2 years of life, but afterwards slightly enhanced in comparison to normal control groups. Other findings like generalised theta paroxysms or focal slow waves were rarely observed. Under a standardised protein load at 6 months (52 patients) and at 5 years of age (42 patients) a moderate generalised slowing of the background activity but no other abnormalities were noted.

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Authors and Affiliations

  1. Kinderklinik, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 150, D-6900, Heidelberg, Federal Republic of Germany

    J. Pietz, D. Sontheimer, Ch. Benninger, B. Pietz, U. Batzler & A. Heusser

  2. Medizinisches Zentrum für Nervenheilkunde, Abteilung Neuroradiologie, Phillips-Universität, D-3550, Marburg, Federal Republic of Germany

    A. Lütcke

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  1. J. Pietz
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Pietz, J., Lütcke, A., Sontheimer, D. et al. EEG development in early treated PKU patients from birth to 6 years of age. Eur J Pediatr 149 (Suppl 1), 28–33 (1990). https://doi.org/10.1007/BF02126296

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