Summary
The purpose of these experiments was to compare the contractile response to ACh of stomach fundal strips from hypertensive (SHR) and normotensive (WKY) rats during the development of hypertension. The results indicate that the reactivity to ACh is the same in fundal strips from young SHR and WKY rats; however, with maturation strips from WKY rats undergo a reduction in responsiveness which does not occur in the SHR. Therefore, strips from older SHR rats are more reactive to ACh than are those from age matched WKY rats.
References
Altman, J., DaPonte, F., and Worcel, M., Br. J. Pharmac.59 (1977) 621.
Kwan, C.Y., Grover, A.K., and Sakai, Y., Blood Vessels19 (1982) 273.
Seidel, C.L., Am. J. Physiol.237 (1979) H34.
Vane, J.R., Br. J. Pharmac. Chemother.12 (1957) 344.
Van Rossum, J.M., and Van Den Brink, F.G., Archs int. Pharmacodyn.143 (1963) 240.
Cohen, M.L., and Wiley, K.S., Clin. exp. Hypertension1 (1979) 761.
Greenberg, S., and Bohr, D.F., Circulation Res.33, suppl. 1 (1974) 1–208.
Peiper, U., Klemt, P., and Popov, R., Basic Res. Cardiol.74 (1979) 21.
Sutter, M.C., and Ljung, B., Acta physiol. scand.99 (1977) 484.
Cohen, M.L., and Berkowitz, B.A., J. Pharmac. exp. Ther.191 (1974) 147.
Ohkawa, H., Jap. J. Physiol.28 (1978) 833.
Seidel, C.L., and Allen, J.C., Am. J. Physiol.237 (1979) C81.
Author information
Authors and Affiliations
Additional information
Acknowledgment. The authors wish to acknowledge the assistance of Mark Kunneman and Elaine Hughes. This work was supported by the following grants: American Heart Association (Texas Affiliate) and National Institutes of Health HL 23815, HL 25349 and HL 24585.
Rights and permissions
About this article
Cite this article
Seidel, C.L., Allen, J.C. & Mukhopadhyay, A. Changes with hypertension and maturation in the response of stomach fundus to acetylcholine. Experientia 40, 691–692 (1984). https://doi.org/10.1007/BF01949725
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01949725