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Untersuchungen zur Liquorgängigkeit von Cefamandol

Investigations on the penetration of cefamandole into spinal fluid

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Zusammenfassung

Nach einmaliger Injektion von 40 mg Cefamandol/kg Körpergewicht wurden bei 20 Probanden im zeitlichen Abstand von 15, 30, 60 und 90 Minuten Liquorproben entnommen und auf ihren Wirkstoffgehalt untersucht. Während im Serum nach zehn Minuten ein mittlerer Höchstwert von 248 mcg/ml ermittelt wurde, konnten im Liquor keinerlei Spuren von Cefamandol festgestellt werden.

Summary

In 20 test persons spinal fluid was taken at intervals of 15, 30, 60 and 90 minutes after a single injection of 40 mg cefamandole/kg body weight in order to determine the levels of the active substance. Whereas in serum an average peak value of 248 mcg/ml was determined after ten minutes, there was no trace at all of cefamandole in the spinal fluid.

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Authors and Affiliations

  1. Klinikum Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer, D-6800, Mannheim

    B. Oellers,  O. Müller &  J. Ungemach

  2. Stadtkrankenhaus Offenbach, D-6050, Offenbach

    K. Fabricius

Authors
  1. B. Oellers
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  2. O. Müller
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  3. J. Ungemach
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  4. K. Fabricius
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Oellers, B., Müller, O., Ungemach, J. et al. Untersuchungen zur Liquorgängigkeit von Cefamandol. Infection 6, 294–296 (1978). https://doi.org/10.1007/BF01641990

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  • DOI: https://doi.org/10.1007/BF01641990

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