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Laboratory studies with BL-S 578 (Cefadroxil) a new broad-spectrum orally active cephalosporin

Laboruntersuchungen mit BL-S 578, einem neuen, oral wirksamen Breitspektrum Cephalosporin

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Summary

BL-S 578 (Cefadroxil) is a new orally active semisynthetic cephalosporin antibiotic with broad-spectrum antibacterial activity. The new compound was evaluatedin vitro in comparison with cephalexin. Some properties studied such as, antibacterial activity, binding with serum proteins and stability in acid and neutral solution at 37° C for both cephalosporins were similar. In experimental infections of mice, the protective action of BL-S 578 was more effective than cephalexin againstStaphylococcus aureus andStreptococcus pneumoniae. BL-S 578 was more resistant than cephalexin to the β-lactamases produced byKlebsiella pneumoniae andEscherichia coli.

Zusammenfassung

BL-S 578 (Cefadroxil) ist ein neues, oral wirksames, halbsynthetisches Cephalosporin Antibiotikum mit einem breiten antibakteriellen Spektrum. Die neue Verbindung wurdein vitro im Vergleich zu Cephalexin untersucht. Einige der geprüften Eigenschaften wie antibakterielle Aktivität, Bindung an Serumproteine und Stabilität in sauerer und neutraler Lösung bei 37° C waren bei beiden Cephalosporinen ähnlich. Bei experimentellen Infektionen in Mäusen war die protektive Wirkung von BL-S 578 effektiver als Cephalexin gegenüberStaphylococcus aureus undStreptococcus pneumoniae. BL-S 578 war gegen die vonKlebsiella pneumoniae undEscherichia coli produzierten β-Laktamasen widerstandsfähiger als Cephalexin.

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Authors and Affiliations

  1. Istituto di Microbiologia, Università degli Studi, Via V. Venanzi 24, I-62032, Camerino, Italy

    S. Ripa &  M. Prenna

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  1. S. Ripa
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  2. M. Prenna
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Erstveröffentlichung: Chemotherapy 25 (1979) 9.

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Ripa, S., Prenna, M. Laboratory studies with BL-S 578 (Cefadroxil) a new broad-spectrum orally active cephalosporin. Infection 8 (Suppl 5), S538–S541 (1980). https://doi.org/10.1007/BF01639666

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  • DOI: https://doi.org/10.1007/BF01639666

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