Summary
No technical difficulties were encountered in visualizing follicles and obtaining aspirates at laparoscopy. At least one oocyte was aspirated in 90% of these women. While the majority of eggs inseminated subsequently cleaved (73%), no pregnancies occurred despite seemingly atraumatic embryo transfer in nearly all women. As two pronuclei were visualized in the majority of cases, one cannot invoke polyspermy as a cause of failure of subsequent embryo development; nor is it possible at this time to segregate those abnormalities in the egg, at the time of oocyte retrieval, from those encountered by normal preimplantation embryos in an abnormal uterine environment, perhaps secondary to hormonal aberrations coincident with gonadotropin stimulus.
This is a preview of subscription content, log in via an institution to check access.
References
Schwartz M, Jewelewicz R: The use of gonadotropins for induction of ovulation. Fertil Steril 1981;35:3–11
Garcia JE, Jones GS, Acosta AF, Wright G Jr: Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration, Phase I, 1981. Fertil Steril 1983;39:167–173
Laufer N, DeCherney AH, Haseltine FP, et al.: The use of high dose human menopausal gonadotropin in an in vitro fertilization program. Fertil Steril 1983;40:734–741
Bronson RA, Cooper GW, Rosenfeld DL: Complement-mediated effects of sperm head-directed human antibodies on the ability of human sperm to penetrate zona-free hamster eggs. Fertil Steril 1983;40:91–95
Lopata A, Johnston IWH, Houst IJ, Speiss AL: Pregnancy following intrauterine implantation of an embryo obtained by in vitro fertilization of a preovulatory egg. Fertil Steril 1980;33:117–120
Jones HW Jr, Jones GS, Andrews MC, et al.: The program for in vitro fertilization at Norfolk. Fertil Steril 1982;38: 14–21
Veeke LL, Wartham JWE Jr, Witmyer J et al.: Maturation and fertilization of morphologically immature human oocytes in a program of in vitro fertilization. Fertil Steril 1983;39:594–602
Trounson AO, Mohr LR, Wood L, Leeton JR: Effect of delayed insemination on in vitro fertilization, culture and transfer of human embryos. J Reprod Fert 1982;64:285–294
Yanagimachi R, Yanagimachi H, Rogers BJ: The use of zona-free animal ova as a test system for the assessment of the fertilizing capacity of human spermatozoa. Biol Reprod 15:471–476, 1976
Edwards RG, Purdy JM: Human Conceptionin vitro London, Academic Press, 1982
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bronson, R.A., Rosenfeld, D.L., Scholl, G.M. et al. In vitro fertilization and embryo transfer at North Shore University Hospital: Initial experiences. J Assist Reprod Genet 1, 204–208 (1984). https://doi.org/10.1007/BF01139214
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01139214