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Synthese und Antitumoraktivität voncis-Dichloroplatin(II)-Komplexen mit Östradiolderivaten

Synthesis and antitumor activity of Pt(II) complexes of estradiol derivatives

  • Organische Chemie Und Bicchemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary

Estrogen-receptor binding moieties were introduced into Pt(II) complexes in order to facilitate the selective transport into cancer cells. Estradiol esters of 2,3-diaminopropionic acid and estradiol ethers of 1,2-diamino-2-methyl-3-(p-hydroxyphenyl)propane were attached to Pt(II) complexes. The antitumor activity of the compounds was tested towards the human mammary carcinoma cell lines MDA-MB 231 and MCF-7, respectively, and the estrogen-receptor binding affinity of the Pt(II) complexes was determined. The steroidal Pt(II) complexes gave a maximum growth inhibition of 80% and a maximum estrogen-receptor binding affinity of 5.18.

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  1. Institut für Anorganische Chemie, Universität Regensburg, D-W-8400, Regensburg, Bundesrepublik Deutschland

    Henri Brunner & Gerhard Sperl

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  1. Henri Brunner
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  2. Gerhard Sperl
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Brunner, H., Sperl, G. Synthese und Antitumoraktivität voncis-Dichloroplatin(II)-Komplexen mit Östradiolderivaten. Monatsh Chem 124, 83–102 (1993). https://doi.org/10.1007/BF00808513

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  • DOI: https://doi.org/10.1007/BF00808513

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