Abstract
Characteristics of the late after-potential (LAP) of amphibian skeletal muscle fibers were studied in low chloride solutions. The LAP elicited by tetanus was larger in magnitude and slower in its time course than the LAP elicited by single spike. The results are in quantitative agreement with predictions based on the theory that the LAP is produced by a potassium accumulation in the transverse tubular system and its time course determined by a diffusion process of the potassium from the tubular lumen into the outside.
Similar content being viewed by others
References
Adrian RH, Freygang WH (1962) The potassium and chloride conductance of frog muscle membrane. J Physiol (Lond) 163:61–103
Freygang WH, Goldstein DA, Hellam DC (1964) The after-potential that follows trains of impulses in frog muscle fibers. J Gen Physiol 47:929–952
Heistracher P, Hunt CC (1969) The relation of membrane changes to contraction in twitch muscle fibers. J Physiol (Lond) 201:589–611
Hill AV (1928) The diffusion of oxygen and lactic acid through tissues. Proc R Soc Lond Ser B 104:39–96
Hino N (1977) Some properties of late after-potential in frog skeletal muscle fiber. Jpn J Physiol 27:235–250
Hodgkin AL, Horowicz P (1959) The influence of potassium and chloride ions on the membrane potential of single muscle fibers. J Physiol (Lond) 148:127–160
Hodgkin AL, Horowicz P (1960) The effects of sudden changes in ionic concentration on the membrane potential of single muscle fibers. J Physiol (Lond) 153:370–385
Kirsch GE, Nichols RA, Nakajima S (1977) Delayed rectification in the transverse tubules. Origin of the late after-potential in frog skeletal muscle. J Gen Physiol 70:1–21
Nakajima S, Nakajima Y, Peachey LD (1973) Speed of repolarization and morphology of glyceroltreated frog muscle fibers. J Physiol (Lond) 234:465–480
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ono, T., Nakajima, S. Time courses of late after-potentials following tetanus or single shock in skeletal muscle fibers. Pflugers Arch. 394, 274–276 (1982). https://doi.org/10.1007/BF00589104
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00589104