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Influence of dichloromethane on the disappearance rate of ethanol in the blood of rats

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Summary

24 Albino-Wistar rats were exposed to dichloromethane-vapours in a concentration of 4200 ppm over a period of 4 hrs after intraperitoneal application of 2.0 g ethanol per kilogram body weight. The disappearance rate of ethanol was measured between the 80th and 240th min after the beginning of the exposure. In comparison to a control group of 24 other rats not exposed to dichloromethane the blood ethanol concentrations turned out to be significantly higher, although an influence of dichloromethane on the ethanol metabolism could not be demonstrated.

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Kassebart, V., Angerer, J. Influence of dichloromethane on the disappearance rate of ethanol in the blood of rats. Int. Arch. Arbeitsmed 33, 231–236 (1974). https://doi.org/10.1007/BF00538921

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  • DOI: https://doi.org/10.1007/BF00538921

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