Summary
24 Albino-Wistar rats were exposed to dichloromethane-vapours in a concentration of 4200 ppm over a period of 4 hrs after intraperitoneal application of 2.0 g ethanol per kilogram body weight. The disappearance rate of ethanol was measured between the 80th and 240th min after the beginning of the exposure. In comparison to a control group of 24 other rats not exposed to dichloromethane the blood ethanol concentrations turned out to be significantly higher, although an influence of dichloromethane on the ethanol metabolism could not be demonstrated.
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References
Browning, E.: Toxicity and metabolism of industrial solvents. Amsterdam: Elsevier 1965
Cornish, H. H., Adefuin, J.: Ethanol potentiation of halogenated aliphatic solvent toxicity. Amer. industr. Hyg. Ass. J. 27, 57–61 (1966)
Di Vincenzo, G. D., Yanno, F. J., Astill, B. D.: The gaschromatographic analysis of methylene chloride in breath, blood and urine. Amer. industr. Hyg. Ass. J. 32, 387–391 (1971)
Di Vincenzo, G. D., Yanno, F. J., Astill, B. D.: Human and canine exposures to methylene chloride vapour. Amer. industr. Hyg. Ass. J. 33, 125–135 (1972)
Fodor, G., Pasjsnar, D., Schlipköter, H. W.: Endogene CO-Bildung durch inkorporierte Halogenkohlenwasserstoffe der Methanreihe. Staub-Reinhal. Luft 33, 258–259 (1973)
Irish, D. D.: Aliphatic halogenated hydrocarbons. In: F. A. Patty, Ed., Industrial hygiene and toxicology, Vol. 2. New York: Interscience 1963
Kuzelova, M., Vlasak, R.: Der Einflu\ von Methylenchlorid auf die Gesundheit der Arbeiter bei der Herstellung von Filmfolien und Ermittlung der Ameisensäure als Stoffwechselprodukt des Methylenchlorids. Pracov. Lék. 18, 167–170 (1966)
Lob, M.: L'action du trichlorethylene sur le taux d'alcool dans le sang. Med. d. Lavoro 51, 587–592 (1960)
Ostle, B.: Statistics in research, 2nd ed. Ames (Iowa): The Iowa State University Press 1963
Paulus, W.: Zur Frage der Vortäuschung eines erhöhten Blutalkoholspiegels durch Einatmen von Trichloräthylen und Tetrachloräthylen. Dtsch. Z. ges. gerichtl. Med. 40, 593–598 (1951)
Riley, E. C., Fassett, D. W., Sutton, W. L.: Methylene chloride vapour in expired air of human subjects. Amer. industr. Hyg. Ass. J. 27, 341–348 (1966)
Stewart, R. D., Fisher, T. N., Hosko, M. J., Peterson, J. E., Baretta, E. D., Dodd, H. C.: Experimental human exposure to methylene chloride. Arch. environm. Hlth 25, 342–348 (1972)
Williams, R. T.: Detoxication mechanisms, 2nd ed., p. 26. New York: Wiley 1959
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Kassebart, V., Angerer, J. Influence of dichloromethane on the disappearance rate of ethanol in the blood of rats. Int. Arch. Arbeitsmed 33, 231–236 (1974). https://doi.org/10.1007/BF00538921
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DOI: https://doi.org/10.1007/BF00538921