Skip to main content
SpringerLink
Log in

Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Chlordiazepoxide and two serotonin receptor antagonists showed opposite effects when tested for their influence on morphine-induced locomotor stimulation in mice. Chlordiazepoxide enhanced morphine-induced hyperactivity, which was antagonized by cyproheptadine and mianserin. The results indicate that the enhancement of morphine-induced locomotor stimulation is not attributable to an antiserotonergic action of the benzodiazepine compound.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Buxbaum DM, Yarbrough GG, Carter ME (1973) Biogenic amines and narcotic effects. I. Modification of morphine-induced analgesia and motor activity after alteration of cerebral amine levels. J Pharmacol Exp Ther 185:317–327

    Google Scholar 

  • Carroll BJ, Sharp PT (1972) Monoamine mediation of morphine-induced activation of mice. Br J Pharmacol 46:124–139

    Google Scholar 

  • Davies C, Sanger DJ, Steinberg H, Tomkiewicz M, U'Prichard DC (1974) Lithium and α-methyl-p-tyrosine prevent manic activity in rodents. Psychopharmacologia 36:263–274

    Google Scholar 

  • Guidotti A, Baraldi M, Leon A, Costa E (1980) Benzodiazepines: A tool to explore the biochemical and neurophysiological basis of anxiety. Fed Proc 39:3039–3042

    Google Scholar 

  • Lison (1961) Statistica applicata alla biologia sperimentale. Casa Editrice Ambrosiana, Milano

    Google Scholar 

  • Maj J, Sowińska H, Baran L, Gancarczyk L, Rawlów A (1978) The central antiserotonergic action of mianserin. Psychopharmacology 59:79–84

    Google Scholar 

  • Oliverio A, Castellano C (1974) Genotype-dependent sensitivity and tolerance to morphine and heroin: Dissociation between opiate-induced running and analgesia in the mouse. Psychopharmacologia 39:13–22

    Google Scholar 

  • Oliverio A, Castellano C, Racagni F, Spano PF, Trabucchi M, Cattabeni C (1978) Genetic aspects in narcotic action. In: Adler ML, Manara L, Samanin R (eds) Factors affecting the action of narcotics Raven, New York, pp 7–18

    Google Scholar 

  • Racagni GF, Bruno E, Iuliano E, Paoletti R (1979) Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: Behavioral and biochemical correlations. J Pharmacol Exp Ther 209:111–116

    Google Scholar 

  • Robson RD, Antonaccio MJ, Saelens JK, Liebman J (1978) Antagonism by mianserin and classical α-adrenoceptor blocking drugs of some cardiovascular and behavioral effects of clonidine. Eur J Pharmacol 47:431–442

    Google Scholar 

  • Sansone M, Ammassari-Teule M, Renzi P, Oliverio A (1981) Different effects of apomorphine on locomotor activity in C57BL/6 and DBA/2 mice. Pharmacol Biochem Behav 14:741–743

    Google Scholar 

  • Sansone M, Oliverio A (1980) Effects of chlordiazepoxide-morphine combinations on spontaneous locomotor activity in three inbred strains of mice. Arch Int Pharmacodyn Ther 247:71–75

    Google Scholar 

  • Sansone M, Renzi P (1981) Avoidance facilitation by chlordiazepoxide-amphetamine combinations in mice: Effect of α-methyl-p-tyrosine. Psychopharmacology 75:22–24

    Google Scholar 

  • Schenberg LC, Graeff FG (1978) Role of periaqueductal gray substance in the antianxiety action of benzodiazepines. Pharmacol Biochem Behav 9:287–295

    Google Scholar 

  • Sepinwall J, Cook L (1980) Mechanism of action of the benzodiazepines: Behavioral aspect. Fed Proc 39:3024–3031

    Google Scholar 

  • Siegfried B, Filibeck U, Gozzo S, Castellano C (1982) Lack of morphine-induced hyperactivity in C57BL/6 mice following striatal kainic acid lesions. Behav Brain Res 4:389–399

    Google Scholar 

  • Stein L, Belluzzi JD, Wise CD (1977) Benzodiazepines: Behavioral and neurochemical mechanisms. Am J Psychiatry 134:665–669

    Google Scholar 

  • van Riezen H (1972) Different central effects of the 5-HT antagonists mianserine and cyproheptadine. Arch Int Pharmacodyn Ther 198:256–269

    Google Scholar 

  • Vargaftig BB, Coignet JL, de Vos CJ, Grijsen H, Bonta JL (1971) Mianserin hydrochloride: Peripheral and central effects in relation to antagonism against 5-hydroxytryptamine and tryptamine. Eur J Pharmacol 16:336–346

    Google Scholar 

  • Vetulani J, Sansone M (1978) Stimulatory effects of chlordiazepoxide on locomotor activity in mice: Importance of noradrenergic transmission. Pol J Pharmacol Pharm 30:791–798

    Google Scholar 

  • Wise CD, Berger BD, Stein L (1972) Benzodiazepines: Anxiety-reducing activity by reduction of serotonin turnover in the brain. Science 177:180–183

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CNR, Istituto di Psicobiologia e Psicofarmacologia, Via Reno 1, I-00198, Roma, Italy

    Mario Sansone

Authors
  1. Mario Sansone
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sansone, M. Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice. Psychopharmacology 78, 54–57 (1982). https://doi.org/10.1007/BF00470588

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00470588

Key words

Search

Navigation