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The size and composition of the submandibular glands in late-onset diabetes

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Summary

Postmortem submandibular glands from 14 patients with late-onset diabetes mellitus were examined in a histomorphometric study and were compared with 14 control glands. The diabetic glands were larger than the control glands and showed increased volume fractions of the stromal components, including vessels, and proportionally less parenchyma. These findings indicate that the increased total volume present in submandibular glands in lateonset diabetes is mainly to increased volumes of fibrous tissue, fat and vessels.

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References

  1. Baumann H, Meyer P, Winter K, Lorenz G (1985) Sialochemische und morphologische Untersuchungen der Glandula submandibularis des Diabetikers — ein Beitrag zur diabetischen Sialadenose. Laryngol Rhinol Otol 64:542–546

    Google Scholar 

  2. Cochran WG (1977) Sampling techniques, 3rd edn. Wiley, New York, p 186

    Google Scholar 

  3. Conner S, Iranpour B, Mills J (1970) Alteration in parotid salivary flow in diabetes mellitus. Oral Surg 30:55–59

    Google Scholar 

  4. Davidson D, Leibel BS, Berris B (1969) Asymptomatic parotid gland enlargement in diabetes mellitus. Ann Intern Med 70:31–38

    Google Scholar 

  5. Donath K, Seifert G (1975) Ultrastructural studies of the parotid glands in sialadenosis. Virchows Arch [A] 365:119–135

    Google Scholar 

  6. High AS, Sutton J, Hopper AH (1985) A morphometric study of submandibular salivary gland changes in streptozotocin-induced diabetic rats. Arch Oral Biol 30:667–671

    Google Scholar 

  7. Murrah VA (1985) Diabetes mellitus and associated oral manifestations: a review. J Oral Pathol 14:271–281

    Google Scholar 

  8. Rao KS, Rao YK (1979) Parotid biopsies in young diabetics. J Indian Med Assoc 72:77–79

    Google Scholar 

  9. Rusotto SB (1981) Asymptomatic parotid gland enlargement in diabetes mellitus. Oral Surg 52:594–598

    Google Scholar 

  10. Scherle W (1970) A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26:57–60

    Google Scholar 

  11. Scott J (1975) Age, sex and contralateral differences in the volumes of human submandibular glands. Arch Oral Biol 20:885–887

    Google Scholar 

  12. Scott J (1977) Quantitative age changes in the histological structure of human submandibular salivary glands. Arch Oral Biol 22:221–227

    Google Scholar 

  13. Sharon A, Beb-Aryeh H, Itzhak B, Yoram K, Szargel R, Gutman D (1985) Salivary composition in diabetic patients. J Oral Med 40:23–26

    Google Scholar 

  14. Sokal RR, Rohlf F (1981) Biometry, 2nd edn. Freeman, New York, pp 402–412

    Google Scholar 

  15. Varletzidis E, Ikkos D, Paleologou G, Pantazopoulos P, Miras K, Adampoulos G (1978) Salivary amylase activity in diabetes mellitus. Panminerva Med 20:255–262

    Google Scholar 

  16. Waterhouse JP, Chisholm DM, Winter RB, Patel M, Yale RS (1973) Replacement of functional parenchymal cells by fat and connective tissue in human submandibular salivary glands: an age-related change. J Oral Pathol 2:16–27

    Google Scholar 

  17. Weibel ER (1979) Stereological methods, vol 1. Academic Press, London

    Google Scholar 

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Lindeberg, H., Andersen, L. The size and composition of the submandibular glands in late-onset diabetes. Arch Otorhinolaryngol 244, 100–103 (1987). https://doi.org/10.1007/BF00458557

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  • DOI: https://doi.org/10.1007/BF00458557

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